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    chst-1 Carbohydrate sulfotransferase chst-1 [ Caenorhabditis elegans ]

    Gene ID: 174304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chst-1
    Official Full Name
    Carbohydrate sulfotransferase chst-1
    Primary source
    WormBase:WBGene00008050
    Locus tag
    CELE_C41C4.1
    See related
    AllianceGenome:WB:WBGene00008050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chondroitin 4-sulfotransferase activity. Involved in chondroitin sulfate biosynthetic process and positive regulation of response to oxidative stress. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chst-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8105609..8106971, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class epsilon-2 Neighboring gene Sideroflexin-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chondroitin 4-O-Sulfotransferase Is Indispensable for Sulfation of Chondroitin and Plays an Important Role in Maintaining Normal Life Span and Oxidative Stress Responses in Nematodes. Izumikawa T, et al. J Biol Chem, 2016 Oct 28. PMID 27645998, Free PMC Article
    2. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Dierker T, et al. Sci Rep, 2016 Oct 5. PMID 27703236, Free PMC Article
    3. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of C41C4.1 in C. elegans resulted in a decline in 4-O-sulfation of chondroitin sulfate and an increase in the number of sulfated units in heparan sulfate.
      Title: Chondroitin 4-O-Sulfotransferase Is Indispensable for Sulfation of Chondroitin and Plays an Important Role in Maintaining Normal Life Span and Oxidative Stress Responses in Nematodes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chondroitin 4-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chondroitin 4-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carbohydrate sulfotransferase chst-1
    NP_495699.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8105609..8106971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063298.6 → NP_495699.1  Carbohydrate sulfotransferase chst-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495699.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09272
      UniProtKB/TrEMBL
      A0A1J1DNA2
      Conserved Domains (1) summary
      pfam03567
      Location:80 → 322
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09272.1

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