twk-7 TWiK family of potassium channels protein 7 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: twk-7
Official Full Name: TWiK family of potassium channels protein 7
Primary source: WormBase:WBGene00006662
Locus tag: CELE_F22B7.7
See related: AllianceGenome:WB:WBGene00006662
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons and ventral nerve cord. Orthologous to human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See twk-7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (8634067..8643739, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we identified TWK-7 as a putative downstream target of the GalphaS-KIN-1/PKA pathway at the level of the gamma-aminobutyric acid (GABA)ergic D-type motor neurons. Due to this epistatic interaction, we suggest that KIN-1/PKA and TWK-7 may share a common pathway that is probably involved in the modulation of both locomotor activity and locomotion behavior during forward crawling.
Title: Locomotion Behavior Is Affected by the Gα(S) Pathway and the Two-Pore-Domain K(+) Channel TWK-7 Interacting in GABAergic Motor Neurons in Caenorhabditis elegans.
we suggest that TWK-7 activity might represent a means to modulate a complex locomotion behavior at the level of certain types of motor neurons.
Title: Complex Locomotion Behavior Changes Are Induced in Caenorhabditis elegans by the Lack of the Regulatory Leak K+ Channel TWK-7.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F22B7.8 (e-PCR)
- UniSTS:322077

F22B7.4 (e-PCR)
- UniSTS:316605

F22B7.7 (e-PCR)
- UniSTS:314101

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: TWiK family of potassium channels protein 7

NP_498903.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8634067..8643739 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066502.6 → NP_498903.3 TWiK family of potassium channels protein 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498903.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P34410, P34411, Q629K0

Conserved Domains (2) summary

pfam00520
Location:371 → 418

Ion_trans; Ion transport protein

pfam07885
Location:263 → 321

Ion_trans_2; Ion channel