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    gop-3 SAM50-like protein gop-3 [ Caenorhabditis elegans ]

    Gene ID: 175723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gop-3
    Official Full Name
    SAM50-like protein gop-3
    Primary source
    WormBase:WBGene00001662
    Locus tag
    CELE_C34E10.1
    See related
    AllianceGenome:WB:WBGene00001662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex assembly and protein insertion into mitochondrial outer membrane. Predicted to be located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human SAMM50 (SAMM50 sorting and assembly machinery component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gop-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (5260694..5263837)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein CLEC16A homolog Neighboring gene GPN-loop GTPase 1 Neighboring gene Uncharacterized protein Neighboring gene Inosine triphosphate pyrophosphatase Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Jian F, et al. Cell Rep, 2018 Jun 5. PMID 29874585
    2. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article
    3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SAM50-like protein gop-3
    NP_498119.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5260694..5263837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065718.8 → NP_498119.1  SAM50-like protein gop-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46576, Q95UF7
      Conserved Domains (1) summary
      pfam01103
      Location:214 → 433
      Bac_surface_Ag; Surface antigen
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46576.2

    Gene LinkOut

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