U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lipl-5 Lipase lipl-5 [ Caenorhabditis elegans ]

    Gene ID: 178563, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lipl-5
    Official Full Name
    Lipase lipl-5
    Primary source
    WormBase:WBGene00022642
    Locus tag
    CELE_ZK6.7
    See related
    AllianceGenome:WB:WBGene00022642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Involved in defense response to Gram-negative bacterium; lipid homeostasis; and triglyceride catabolic process. Located in lysosome. Is expressed in coelomocyte and intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lipl-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (385746..387740)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MLt-TeN (mlt-10) related Neighboring gene ncRNA Neighboring gene UNC93-like protein MFSD11 Neighboring gene UNC93-like protein MFSD11 Neighboring gene Nuclear Hormone Receptor family

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Macedo F, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Feb. PMID 31676440
    2. Sex differences in body composition, fat storage, and gene expression profile in Caenorhabditis elegans in response to dietary restriction. Miersch C, et al. Physiol Genomics, 2013 Jul 2. PMID 23715261
    3. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Buis A, et al. Cell Rep, 2019 Jul 23. PMID 31340142, Free PMC Article
    4. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. O'Rourke EJ, et al. Nat Cell Biol, 2013 Jun. PMID 23604316, Free PMC Article
    5. Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways. Liu J, et al. Appl Environ Microbiol, 2013 Dec. PMID 24056462, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
      Title: Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
    2. Study characterized the lipid profile of Caenorhabditis elegans lipl-5 mutants, deficient for the LIPL-5 lipase, compared them with wild type worms, and found major alterations in mitochondrial lipids in the mutants, which were accompanied by significant changes in mitochondrial activity. Results indicate that LIPL-5 lipase is a determinant of mitochondrial functional remodeling in response to food withdrawal.
      Title: Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Lipase lipl-5
    NP_001360404.1
    • Confirmed by transcript evidence
    NP_001368575.1
    • Confirmed by transcript evidence
    NP_503184.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      385746..387740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070783.5 → NP_503184.1  Lipase lipl-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AW68, A0A0K3AYF1, O61866
      Conserved Domains (1) summary
      PLN02872
      Location:8 → 394
      PLN02872; triacylglycerol lipase

    2. NM_001380590.1 → NP_001368575.1  Lipase lipl-5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PLN02872
      Location:5 → 368
      PLN02872; triacylglycerol lipase

    3. NM_001372991.2 → NP_001360404.1  Lipase lipl-5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PLN02872
      Location:1 → 318
      PLN02872; triacylglycerol lipase

    RNA

    1. NR_132475.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61866.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools