SGV1 cyclin-dependent serine/threonine protein kinase SGV1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SGV1
Official Full Name: cyclin-dependent serine/threonine protein kinase SGV1
Primary source: SGD:S000006365
Locus tag: YPR161C
See related: AllianceGenome:SGD:S000006365; FungiDB:YPR161C; VEuPathDB:YPR161C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BUR1
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of transcription elongation by RNA polymerase II and transcription elongation by RNA polymerase II. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Used to study renal carcinoma. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SGV1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (864449..866422, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Bur1 cyclin-dependent kinase regulates telomere length in Saccharomyces cerevisiae.
Title: The Bur1 cyclin-dependent kinase regulates telomere length in Saccharomyces cerevisiae.
Bur1 functions with TORC1 for vacuole-mediated cell cycle progression.
Title: Bur1 functions with TORC1 for vacuole-mediated cell cycle progression.
Results provide evidence that Bur1 phosphorylates residues in the Rpb1 linker region.
Title: Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo.
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Title: Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
Bur1-Bur2 interacts with RPA and maintains genome integrity during DNA replication stress
Title: The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.
Data show that Bur1 phosphorylates the Spt5 C-terminal repeat domain (CTD) both in vivo and in isolated elongation complexes in vitro.
Title: Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
Spt5 C-terminal domain is a substrate of BUR kinase and a platform for the association of proteins that promote both transcription elongation and histone modification in transcribed regions
Title: Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.
The findings provide evidence that histone modifications at the 5' and 3' ends of coding regions are regulated by distinct mechanisms and reveal that the Bur1-Bur2 and Paf1 complexes repress cryptic transcription through a Set2-independent pathway.
Title: Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes.
the interactions linking Cak1 with the PAF1 complex and with Ssu72 are not direct but mediated via Ctk1 and Bur1
Title: Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1.
In vivo identified substrates for Bur1 link its role to transcriptional elongation and demonstrate a potential activation mechanism for histone H2B monoubiquitination by the Rad6/Bre1 complex.
Title: The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of serine/threonine protein kinase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent serine/threonine protein kinase SGV1

NP_015487.1

EC 2.7.11.22

EC 2.7.11.23

Cyclin (Bur2p)-dependent protein kinase; subunit of the CDK-cyclin BUR kinase complex with Bur2p; regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; stimulates recruitment of the PAF complex through Spt5p CTD phosphorylation; recruits Spt6p to the CTD at the onset of transcription; regulates telomere elongation; regulated by Cak1p; similar to metazoan CDK9 proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

864449..866422 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184258.1 → NP_015487.1 TPA: cyclin-dependent serine/threonine protein kinase SGV1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015487.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4G2, P23293

UniProtKB/TrEMBL

B3LKC2, C8ZJI7, G2WPX4, N1P2G7

Conserved Domains (1) summary

cd07866
Location:50 → 366

STKc_BUR1; Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins