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    dom-3 Decapping nuclease dom-3 [ Caenorhabditis elegans ]

    Gene ID: 172124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dom-3
    Official Full Name
    Decapping nuclease dom-3
    Primary source
    WormBase:WBGene00001050
    Locus tag
    CELE_F54C1.2
    See related
    AllianceGenome:WB:WBGene00001050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 5'-diphosphatase activity. Predicted to be involved in NAD-cap decapping and nuclear-transcribed mRNA catabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dom-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (5003450..5004933)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 30 homolog Neighboring gene Polycomb protein mes-3 Neighboring gene Uncharacterized protein Neighboring gene Sperm Specific Transcript Neighboring gene glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans. Shen Y, et al. J Neurosci, 2014 Oct 1. PMID 25274815, Free PMC Article
    2. Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans. Paulsen JE, et al. Genetics, 1995 Dec. PMID 8601481, Free PMC Article
    3. Trans-splicing and polycistronic transcription in Caenorhabditis elegans. Blumenthal T. Trends Genet, 1995 Apr. PMID 7732590
    4. Caenorhabditis elegans operons: form and function. Blumenthal T, et al. Nat Rev Genet, 2003 Feb. PMID 12560808
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA NAD+-cap (NAD+-forming) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Decapping nuclease dom-3
    NP_491496.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5003450..5004933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059095.8 → NP_491496.1  Decapping nuclease dom-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10660
      Conserved Domains (1) summary
      pfam08652
      Location:266 → 315
      RAI1; RAI1 like PD-(D/E)XK nuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10660.1

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