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    app-1 Xaa-Pro aminopeptidase app-1 [ Caenorhabditis elegans ]

    Gene ID: 172118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    app-1
    Official Full Name
    Xaa-Pro aminopeptidase app-1
    Primary source
    WormBase:WBGene00000155
    Locus tag
    CELE_W03G9.4
    See related
    AllianceGenome:WB:WBGene00000155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables metalloaminopeptidase activity; protein homodimerization activity; and zinc ion binding activity. Involved in proteolysis involved in protein catabolic process. Located in cytoplasm. Is expressed in intestine. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to several human genes including XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See app-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (4964667..4967089, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ENhancer of Uncoordination Neighboring gene Protein pid-4 Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site. Iyer S, et al. FEBS Open Bio, 2015. PMID 25905034, Free PMC Article
    2. Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans. Laurent V, et al. Eur J Biochem, 2001 Oct. PMID 11606206
    3. Proline-specific aminopeptidase P prevents replication-associated genome instability. Silva N, et al. PLoS Genet, 2022 Jan. PMID 35081133, Free PMC Article
    4. Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo. Placentino M, et al. EMBO J, 2021 Feb 1. PMID 33231880, Free PMC Article
    5. PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins. Hsieh HC, et al. Autophagy, 2024 Jun. PMID 38261662, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proline-specific aminopeptidase P prevents replication-associated genome instability.
      Title: Proline-specific aminopeptidase P prevents replication-associated genome instability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Xaa-Pro aminopeptidase app-1
    NP_491489.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4964667..4967089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059088.8 → NP_491489.1  Xaa-Pro aminopeptidase app-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491489.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44750
      Conserved Domains (4) summary
      cd01085
      Location:325 → 547
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:552 → 616
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:159 → 322
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:54 → 141
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44750.1

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