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    • Showing Current items.

    unc-50 Protein unc-50 [ Caenorhabditis elegans ]

    Gene ID: 176443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-50
    Official Full Name
    Protein unc-50
    Primary source
    WormBase:WBGene00006785
    Locus tag
    CELE_T07A5.2
    See related
    AllianceGenome:WB:WBGene00006785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in receptor localization to synapse and regulation of muscle contraction. Located in Golgi membrane. Is expressed in several structures, including alimentary muscle; gonad; intestine; neurons; and vulval muscle. Orthologous to human UNC50 (unc-50 inner nuclear membrane RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-50 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10314523..10318162, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative vesicular glutamate transporter vglu-3 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Short coiled-coil protein;Short coiled-coil protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis. Abiusi E, et al. Hum Mol Genet, 2017 Oct 15. PMID 29016857
    2. An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans. Sakube Y, et al. J Mol Biol, 1997 Apr 11. PMID 9135117
    3. 1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction. Sammi SR, et al. Mol Neurobiol, 2017 Sep. PMID 27599497
    4. Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission. Sammi SR, et al. Eur J Pharmacol, 2018 Jan 5. PMID 29074413
    5. Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor. Boulin T, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19020092, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the transmembrane Golgi protein UNC-50 has a role in regulation of nicotinic receptor trafficking
      Title: Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein unc-50
    NP_499279.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10314523..10318162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066878.5 → NP_499279.2  Protein unc-50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499279.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10045
      Conserved Domains (1) summary
      pfam05216
      Location:65 → 284
      UNC-50; UNC-50 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10045.2

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