F38B6.4 Phosphoribosylglycinamide formyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F38B6.4
Official Full Name: Phosphoribosylglycinamide formyltransferase
Primary source: WormBase:WBGene00018174
Locus tag: CELE_F38B6.4
See related: AllianceGenome:WB:WBGene00018174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Predicted to be involved in adenine biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytosol. Is expressed in intestinal cell. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F38B6.4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (6674869..6679848)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F38B6.4 (e-PCR)
- UniSTS:310199

F38B6.5 (e-PCR)
- UniSTS:310200

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylamine-glycine ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylglycinamide formyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in adenine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Phosphoribosylglycinamide formyltransferase

NP_509122.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6674869..6679848

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076721.7 → NP_509122.2 Phosphoribosylglycinamide formyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509122.2

Status: REVIEWED

UniProtKB/TrEMBL

Q20143

Conserved Domains (7) summary

cd02196
Location:456 → 758

PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...

cd08645
Location:788 → 968

FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)

PRK00885
Location:1 → 415

PRK00885; phosphoribosylamine--glycine ligase; Provisional

PRK05385
Location:424 → 757

PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

pfam01071
Location:100 → 292

GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain

pfam02843
Location:328 → 415

GARS_C; Phosphoribosylglycinamide synthetase, C domain

pfam02844
Location:2 → 99

GARS_N; Phosphoribosylglycinamide synthetase, N domain