dhc-1 Dynein heavy chain, cytoplasmic;Dynein heavy chain, cytosolic [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhc-1
Official Full Name: Dynein heavy chain, cytoplasmic;Dynein heavy chain, cytosolic
Primary source: WormBase:WBGene00000962
Locus tag: CELE_T21E12.4
See related: AllianceGenome:WB:WBGene00000962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including axonal transport; establishment of meiotic spindle orientation; and maintenance of centrosome location. Located in several cellular components, including kinetochore; nuclear envelope; and spindle pole. Is expressed in several structures, including anal depressor muscle; germ line; head; pharynx; and somatic cell. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant intellectual developmental disorder 13; and spinal muscular atrophy with lower extremity predominant 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (4386785..4401907)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both LIS-1 and the dynein heavy-chain DHC-1 are required for integrity of the actin cytoskeleton in C. elegans.
Title: Regulators of the actin cytoskeleton mediate lethality in a Caenorhabditis elegans dhc-1 mutant.
The polarity-induced force imbalance in Caenorhabditis elegans embryos is caused by asymmetric binding rates of dynein to the cortex.
Title: The polarity-induced force imbalance in Caenorhabditis elegans embryos is caused by asymmetric binding rates of dynein to the cortex.
Data indicate a role for DHC-1, the dynein heavy chain, in maintaining neuronal cargo distribution.
Title: Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.
Dynein tethered to the cell cortex generates pulling forces that position the mitotic spindle. Two distinct cortical dynein populations together create a robust force-generating system in the polarized one-cell Caenorhabditis elegans embryo.
Title: Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos.
we dissect the role of dynactin's microtubule binding activity, located in the p150 CAP-Gly domain and an adjacent basic patch, in the C. elegans zygote. Our results suggest that p150 GAP-Gly domain binding to microtubules promotes initiation of dynein-mediated organelle transport in the dividing one-cell embryo, and that this function of p150 is critical for generating cytoplasmic pulling forces for centrosome
Title: Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport.
Mutations affecting dhc-1 and cyb-3 cooperate to increase fitness in the absence of MDF-1.
Title: Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.
Data present evidence that bicd-1 operates in a conserved pathway with dhc-1 and unc-116.
Title: C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.
Data show that accumulation of dynein at poles was kinesin-1 independent and APC dependent, just like dynein driven spindle movements.
Title: Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans.
Dhc-1, as well as the dynactin components dnc-1 (p150Glued) and dnc-2 (p50/dynamitin), are essential for LIS-1 targeting to the nuclear periphery.
Title: lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.
mutational analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans
Title: Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21E12.4 (e-PCR)
- UniSTS:310931

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterograde neuronal dense core vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of meiotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of meiotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of centrosome location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dense core granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dynein heavy chain, cytoplasmic;Dynein heavy chain, cytosolic

NP_001317773.1

Confirmed by transcript evidence

NP_491363.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4386785..4401907

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058962.7 → NP_491363.1 Dynein heavy chain, cytoplasmic [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491363.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19020

Conserved Domains (8) summary

COG5245
Location:985 → 4276

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3872 → 4549

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:236 → 811

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1291 → 1687

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3144 → 3475

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3504 → 3719

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2769 → 2879

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1827 → 2055

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001330925.3 → NP_001317773.1 Dynein heavy chain, cytosolic [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A163VTS9