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    • Showing Current items.

    serr-1 L-serine ammonia-lyase [ Caenorhabditis elegans ]

    Gene ID: 187970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serr-1
    Official Full Name
    L-serine ammonia-lyase
    Primary source
    WormBase:WBGene00011353
    Locus tag
    CELE_T01H8.2
    See related
    AllianceGenome:WB:WBGene00011353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including L-serine ammonia-lyase activity; amino-acid racemase activity; and heterocyclic compound binding activity. Predicted to be involved in D-serine biosynthetic process. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See serr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (8571556..8573749, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene LSDAT_euk domain-containing protein;Transient receptor potential channel Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase Neighboring gene Smad protein daf-8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a homologue of mammalian serine racemase from Caenorhabditis elegans: the enzyme is not critical for the metabolism of serine in vivo. Katane M, et al. Genes Cells, 2016 Sep. PMID 27458110
    2. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. Saitoh Y, et al. J Neurosci, 2020 Sep 23. PMID 32855271, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L-serine ammonia-lyase
    NP_492318.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8571556..8573749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059917.3 → NP_492318.1  L-serine ammonia-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93968
      Conserved Domains (1) summary
      cd01562
      Location:7 → 311
      Thr-dehyd; Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly ...
    Nucleotide Protein
    Heading Accession and Version

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