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    cln-3.1 Battenin [ Caenorhabditis elegans ]

    Gene ID: 179559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cln-3.1
    Official Full Name
    Battenin
    Primary source
    WormBase:WBGene00000539
    Locus tag
    CELE_F07B10.1
    See related
    AllianceGenome:WB:WBGene00000539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in determination of adult lifespan and regulation of egg-laying behavior. Located in cytoplasm. Is expressed in cuticle; diagonal muscle; hypodermis; intestine; and pharynx. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cln-3.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (11263330..11265652, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype. de Voer G, et al. J Inherit Metab Dis, 2005. PMID 16435200
    2. Genomic structure of three CLN3-like genes in Caenorhabditis elegans. Mitchell WA, et al. Eur J Paediatr Neurol, 2001. PMID 11588982
    3. Caenorhabditis elegans homologues of the CLN3 gene, mutated in juvenile neuronal ceroid lipofuscinosis. De Voer G, et al. Eur J Paediatr Neurol, 2001. PMID 11588981
    4. GATA transcription factor required for immunity to bacterial and fungal pathogens. Kerry S, et al. PLoS One, 2006 Dec 20. PMID 17183709, Free PMC Article
    5. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Battenin
    NP_001256315.1
    • Confirmed by transcript evidence
    NP_001256316.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11263330..11265652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269387.2 → NP_001256316.1  Battenin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU35
      Conserved Domains (1) summary
      pfam02487
      Location:24 → 380
      CLN3; CLN3 protein

    2. NM_001269386.3 → NP_001256315.1  Battenin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBM4
      Conserved Domains (1) summary
      pfam02487
      Location:12 → 417
      CLN3; CLN3 protein
    Nucleotide Protein
    Heading Accession and Version

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