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    mop-25.2 MO25-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 174527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mop-25.2
    Official Full Name
    MO25-like protein 2
    Primary source
    WormBase:WBGene00013140
    Locus tag
    CELE_Y53C12A.4
    See related
    AllianceGenome:WB:WBGene00013140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Involved in asymmetric neuroblast division. Predicted to be located in cytoplasm and spindle pole. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39) and CAB39L (calcium binding protein 39 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mop-25.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (9701402..9703701, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-like peptide 11 Neighboring gene Expressed conserved protein Neighboring gene HEAT repeat-containing protein Neighboring gene tRNA-uridine aminocarboxypropyltransferase 1 Neighboring gene Protein YIPF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interrogating the ccm-3 Gene Network. Lant B, et al. Cell Rep, 2018 Sep 11. PMID 30208312
    2. Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions. Chien SC, et al. Genetics, 2013 Mar. PMID 23267054, Free PMC Article
    3. Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Denning DP, et al. Nature, 2012 Aug 9. PMID 22801495, Free PMC Article
    4. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
    5. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MO25-like protein 2
    NP_496092.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9701402..9703701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063691.6 → NP_496092.1  MO25-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18211
      Conserved Domains (1) summary
      pfam08569
      Location:5 → 336
      Mo25; Mo25-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18211.1

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