ercc-1 ERCC1-like central domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ercc-1
Official Full Name: ERCC1-like central domain-containing protein
Primary source: WormBase:WBGene00008665
Locus tag: CELE_F10G8.7
See related: AllianceGenome:WB:WBGene00008665
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity and identical protein binding activity. Involved in UV-damage excision repair and base-excision repair. Predicted to be located in nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ercc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (10030174..10046760)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
Title: Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10G8.7 (e-PCR)
- UniSTS:322050

F10G8.5 (e-PCR)
- UniSTS:315698

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in UV-damage excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in UV-damage excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ERCC4-ERCC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ERCC1-like central domain-containing protein

NP_001369985.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10030174..10046760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383709.2 → NP_001369985.1 ERCC1-like central domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q93456

Conserved Domains (2) summary

PRK14666
Location:184 → 252

uvrC; excinuclease ABC subunit C; Provisional

pfam03834
Location:50 → 165

Rad10; Binding domain of DNA repair protein Ercc1 (rad10/Swi10)