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    apb-3 AP-3 complex subunit beta [ Caenorhabditis elegans ]

    Gene ID: 172553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apb-3
    Official Full Name
    AP-3 complex subunit beta
    Primary source
    WormBase:WBGene00000163
    Locus tag
    CELE_R11A5.1
    See related
    AllianceGenome:WB:WBGene00000163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryo development and lysosome organization. Predicted to be located in axon cytoplasm and clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome (multiple); developmental and epileptic encephalopathy 48; interstitial lung disease (multiple); and neutropenia. Orthologous to several human genes including AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See apb-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7853750..7857853)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 60;histone acetyltransferase Neighboring gene MATH domain-containing protein Neighboring gene Transcription initiation factor TFIID subunit 5 Neighboring gene Protein nud-2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. Harrington AJ, et al. J Neurosci, 2012 Feb 8. PMID 22323726, Free PMC Article
    2. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
    3. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article
    4. LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α. Nadiminti SSP, et al. PLoS Genet, 2024 May. PMID 38722918, Free PMC Article
    5. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. Holmes A, et al. J Cell Sci, 2007 Aug 1. PMID 17636000

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit beta
    NP_492170.2
    • Confirmed by transcript evidence
    NP_492171.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7853750..7857853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059769.6 → NP_492170.2  AP-3 complex subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492170.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45718
      Conserved Domains (4) summary
      cl22853
      Location:35 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam01602
      Location:23 → 546
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:740 → 826
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      sd00044
      Location:100 → 128
      HEAT; HEAT repeat [structural motif]

    2. NM_059770.6 → NP_492171.2  AP-3 complex subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492171.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62348
      Conserved Domains (4) summary
      cl22853
      Location:35 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam01602
      Location:23 → 536
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:730 → 816
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      sd00044
      Location:100 → 128
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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