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    myo-3 Myosin-3 [ Caenorhabditis elegans ]

    Gene ID: 179676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo-3
    Official Full Name
    Myosin-3
    Primary source
    WormBase:WBGene00003515
    Locus tag
    CELE_K12F2.1
    See related
    AllianceGenome:WB:WBGene00003515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cytoskeletal motor activity. Involved in locomotory behavior and positive regulation of ovulation. Located in A band and striated muscle myosin thick filament. Is expressed in body wall musculature; gonad; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See myo-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (12226817..12234343, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein vab-8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detrimental effects of fructose on mitochondria in mouse motor neurons and on C. elegans healthspan. Lodha D, et al. Nutr Neurosci, 2022 Jun. PMID 33258406
    2. RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement. Abu-Baker A, et al. Mol Ther Nucleic Acids, 2019 Apr 15. PMID 30831428, Free PMC Article
    3. The minor myosin heavy chain, mhcA, of Caenorhabditis elegans is necessary for the initiation of thick filament assembly. Waterston RH. EMBO J, 1989 Nov. PMID 2583106, Free PMC Article
    4. WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Xian B, et al. Aging Cell, 2013 Jun. PMID 23442149
    5. A novel fluorescent timer based on bicistronic expression strategy in Caenorhabditis elegans. Chen MR, et al. Biochem Biophys Res Commun, 2010 Apr 23. PMID 20350530

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle myosin thick filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle myosin thick filament IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myosin-3
    NP_506065.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12226817..12234343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073664.7 → NP_506065.2  Myosin-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506065.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12844, Q21440
      Conserved Domains (6) summary
      cd01377
      Location:100 → 779
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:88 → 779
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:857 → 1937
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam16043
      Location:932 → 1090
      DUF4795; Domain of unknown function (DUF4795)
      cl02488
      Location:1186 → 1391
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12844.1

    Gene LinkOut

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