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    gcy-14 Receptor-type guanylate cyclase gcy-14 [ Caenorhabditis elegans ]

    Gene ID: 191647, updated on 9-Dec-2024

    Summary

    Official Symbol
    gcy-14
    Official Full Name
    Receptor-type guanylate cyclase gcy-14
    Primary source
    WormBase:WBGene00001540
    Locus tag
    CELE_ZC412.2
    See related
    AllianceGenome:WB:WBGene00001540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in several processes, including response to alkaline pH; response to lithium ion; and response to salt. Predicted to be located in cilium. Predicted to be active in plasma membrane. Is expressed in ASEL; AWCL; AWCR; and PVT. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See gcy-14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (14863134..14868281, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene tRNA-Cys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Abnormal cell migration protein 18-like fibronectin type I domain-containing protein;Sushi domain-containing protein Neighboring gene UDENN domain-containing protein

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lithium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Receptor-type guanylate cyclase gcy-14
    NP_506660.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14863134..14868281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074259.5NP_506660.2  Receptor-type guanylate cyclase gcy-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506660.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G1UJJ4, Q23310
      Conserved Domains (6) summary
      cd06352
      Location:21423
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:8391031
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:8661053
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:43418
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:817860
      HNOBA; Heme NO binding associated
      cl21453
      Location:535800
      PKc_like; Protein Kinases, catalytic domain