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    ubc-7 putative ubiquitin-conjugating enzyme E2 7 [ Caenorhabditis elegans ]

    Gene ID: 176363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubc-7
    Official Full Name
    putative ubiquitin-conjugating enzyme E2 7
    Primary source
    WormBase:WBGene00006704
    Locus tag
    CELE_F58A4.10
    See related
    AllianceGenome:WB:WBGene00006704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ubc-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9630097..9631167, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tubulin gamma chain Neighboring gene putative DNA-directed RNA polymerases I and III subunit RPAC2 Neighboring gene Gex-3-interacting protein 13 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Individual point mutations in two ERAD E2 ubiquitin-conjugating enzymes do not affect Caenorhabditis elegans spontaneous reversal frequency. Oswald M, et al. MicroPubl Biol, 2020 Nov 19. PMID 33274319, Free PMC Article
    2. O-GlcNAcylation confers protection against Staphylococcus aureus infection in Caenorhabditis elegans through ubiquitination. Vigneshwari L, et al. RSC Adv, 2018 Jun 21. PMID 35540126, Free PMC Article
    3. Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein. Vartiainen S, et al. Neurobiol Dis, 2006 Jun. PMID 16626960
    4. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Springer W, et al. Hum Mol Genet, 2005 Nov 15. PMID 16204351
    5. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ubiquitin-conjugating enzyme E2 7
    NP_499133.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9630097..9631167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066732.7 → NP_499133.1  putative ubiquitin-conjugating enzyme E2 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34477
      Conserved Domains (1) summary
      COG5078
      Location:8 → 161
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34477.1

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