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    mec-18 AMP-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mec-18
    Official Full Name
    AMP-binding domain-containing protein
    Primary source
    WormBase:WBGene00003179
    Locus tag
    CELE_C52B9.9
    See related
    AllianceGenome:WB:WBGene00003179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable CoA-ligase activity. Involved in detection of mechanical stimulus involved in sensory perception of touch and mechanosensory behavior. Located in neuron projection and neuronal cell body. Is expressed in PLML and PLMR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mec-18 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (4271165..4274216, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GOST seven transmembrane domain-containing protein Neighboring gene ncRNA Neighboring gene Tubulin-specific chaperone cofactor E-like protein Neighboring gene Uncharacterized protein Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene ETS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Schaefer AM, et al. Neuron, 2000 May. PMID 10839354
    2. The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur DS, et al. Nature, 2002 Dec 12. PMID 12478294
    3. MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity. Zhang Y, et al. Mech Dev, 2002 Nov. PMID 12385749
    4. Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Chalfie M, et al. Science, 1989 Feb 24. PMID 2646709
    5. The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Qin H, et al. Dev Biol, 2004 Jun 1. PMID 15136141

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables CoA-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CoA-ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AMP-binding domain-containing protein
    NP_508731.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4271165..4274216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076330.8 → NP_508731.3  AMP-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508731.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45873
      Conserved Domains (2) summary
      COG0318
      Location:12 → 585
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      cl17068
      Location:35 → 579
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version

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