npp-18 Nucleoporin SEH1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-18
Official Full Name: Nucleoporin SEH1
Primary source: WormBase:WBGene00003804
Locus tag: CELE_Y43F4B.4
See related: AllianceGenome:WB:WBGene00003804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable structural molecule activity. Predicted to be involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Predicted to be located in lysosomal membrane and nuclear envelope. Predicted to be part of Seh1-associated complex and nuclear pore outer ring. Is expressed in intestine; nervous system; pharynx; and rectal gland cell. Orthologous to human SEH1L (SEH1 like nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npp-18 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (13296853..13298993)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y43F4B.4 (e-PCR)
- UniSTS:315214

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Seh1-associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nucleoporin SEH1

NP_499740.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13296853..13298993

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067339.6 → NP_499740.1 Nucleoporin SEH1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499740.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45933

Conserved Domains (3) summary

COG2319
Location:11 → 338

WD40; WD40 repeat [General function prediction only]

sd00039
Location:21 → 60

7WD40; WD40 repeat [structural motif]

cl02567
Location:5 → 250

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...