U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ifa-1 Intermediate filament protein A;Intermediate filament protein ifa-1 [ Caenorhabditis elegans ]

    Gene ID: 181316, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ifa-1
    Official Full Name
    Intermediate filament protein A;Intermediate filament protein ifa-1
    Primary source
    WormBase:WBGene00002050
    Locus tag
    CELE_F38B2.1
    See related
    AllianceGenome:WB:WBGene00002050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Located in intermediate filament. Is expressed in several structures, including egg-laying apparatus; excretory cell; neurons; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ifa-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (11271182..11275498)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Metallo-beta-lactamase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system. Karabinos A, et al. J Mol Biol, 2003 Oct 17. PMID 14529618
    2. Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans. Dodemont H, et al. EMBO J, 1994 Jun 1. PMID 8013462, Free PMC Article
    3. Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Lamitina ST, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15496475
    4. Loss of intermediate filament IFB-1 reduces mobility, density, and physiological function of mitochondria in Caenorhabditis elegans sensory neurons. Barmaver SN, et al. Traffic, 2022 May. PMID 35261124
    5. Promiscuous Dimerization Between the Caenorhabditis elegans IF Proteins and a Hypothesis to Explain How Multiple IFs Persist Over Evolutionary Time. Karabinos A, et al. J Mol Evol, 2019 Sep. PMID 31407015

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFA-1 and IFB-1 form a heteropolymeric intermediate filaments system in the C. elegans tissue.
      Title: Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Intermediate filament protein A;Intermediate filament protein ifa-1
    NP_001076764.1
    • Confirmed by transcript evidence
    NP_001257139.1
    • Confirmed by transcript evidence
    NP_001360640.1
    • Confirmed by transcript evidence
    NP_741902.1
    • Confirmed by transcript evidence
    NP_741903.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11271182..11275498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171777.9 → NP_741902.1  Intermediate filament protein ifa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECT5, P90901, Q0G822, Q17599, Q20141, Q8MLX8
      Conserved Domains (4) summary
      pfam00038
      Location:69 → 421
      Filament; Intermediate filament protein
      pfam00932
      Location:460 → 568
      LTD; Lamin Tail Domain
      pfam15898
      Location:116 → 213
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl03075
      Location:179 → 251
      GrpE; nucleotide exchange factor GrpE

    2. NM_001270210.4 → NP_001257139.1  Intermediate filament protein ifa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90901
      Conserved Domains (4) summary
      pfam00038
      Location:86 → 438
      Filament; Intermediate filament protein
      pfam00932
      Location:477 → 585
      LTD; Lamin Tail Domain
      pfam15898
      Location:133 → 230
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl03075
      Location:196 → 268
      GrpE; nucleotide exchange factor GrpE

    3. NM_171778.7 → NP_741903.1  Intermediate filament protein ifa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90901
      Conserved Domains (4) summary
      pfam00038
      Location:69 → 421
      Filament; Intermediate filament protein
      pfam00932
      Location:460 → 568
      LTD; Lamin Tail Domain
      pfam15898
      Location:116 → 213
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl03075
      Location:179 → 251
      GrpE; nucleotide exchange factor GrpE

    4. NM_001373503.1 → NP_001360640.1  Intermediate filament protein A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IIR6
      Conserved Domains (1) summary
      pfam00038
      Location:98 → 450
      Filament; Intermediate filament protein

    5. NM_001083295.4 → NP_001076764.1  Intermediate filament protein ifa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90901
      Conserved Domains (4) summary
      pfam00038
      Location:61 → 413
      Filament; Intermediate filament protein
      pfam00932
      Location:452 → 560
      LTD; Lamin Tail Domain
      pfam15898
      Location:108 → 205
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl03075
      Location:171 → 243
      GrpE; nucleotide exchange factor GrpE
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90901.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.