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    ifc-1 Intermediate filament protein ifc-1 [ Caenorhabditis elegans ]

    Gene ID: 178747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifc-1
    Official Full Name
    Intermediate filament protein ifc-1
    Primary source
    WormBase:WBGene00002055
    Locus tag
    CELE_F37B4.2
    See related
    AllianceGenome:WB:WBGene00002055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; Meesmann corneal dystrophy 2; epidermolysis bullosa simplex (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT1 (keratin 1); KRT10 (keratin 10); and KRT2 (keratin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifc-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (2881393..2883753)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Seven TM Receptor Neighboring gene Serpentine Receptor, class E (epsilon) Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans. Dodemont H, et al. EMBO J, 1994 Jun 1. PMID 8013462, Free PMC Article
    2. Promiscuous Dimerization Between the Caenorhabditis elegans IF Proteins and a Hypothesis to Explain How Multiple IFs Persist Over Evolutionary Time. Karabinos A, et al. J Mol Evol, 2019 Sep. PMID 31407015
    3. Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs. Karabinos A. Gene, 2019 Apr 15. PMID 30641223
    4. Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions. Geisler F, et al. Elife, 2023 Jun 7. PMID 37283438, Free PMC Article
    5. Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans. Karabinos A, et al. Gene Expr Patterns, 2019 Dec. PMID 31207388

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Intermediate filament protein ifc-1
    NP_503783.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2881393..2883753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071382.7 → NP_503783.1  Intermediate filament protein ifc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45168, Q21066
      Conserved Domains (3) summary
      pfam00038
      Location:33 → 378
      Filament; Intermediate filament protein
      pfam15847
      Location:386 → 487
      Loricrin; Major keratinocyte cell envelope protein
      cl01807
      Location:382 → 484
      DUF1517; Protein of unknown function (DUF1517)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45168.2

    Gene LinkOut

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