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    ncx-2 Calx-beta domain-containing protein;Sodium/calcium exchanger membrane region domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncx-2
    Official Full Name
    Calx-beta domain-containing protein;Sodium/calcium exchanger membrane region domain-containing protein
    Primary source
    WormBase:WBGene00003567
    Locus tag
    CELE_C10G8.5
    See related
    AllianceGenome:WB:WBGene00003567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in body wall musculature; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncx-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (5303689..5311270)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene Headcase N-terminal domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
    2. Cell-specific proteomic analysis in Caenorhabditis elegans. Yuet KP, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691744, Free PMC Article
    3. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article
    4. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calx-beta domain-containing protein;Sodium/calcium exchanger membrane region domain-containing protein
    NP_001023643.1
    • Confirmed by transcript evidence
    NP_001023644.1
    • Confirmed by transcript evidence
    NP_504414.4
    • Confirmed by transcript evidence
    NP_504415.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5303689..5311270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072013.8 → NP_504414.4  Calx-beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504414.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYP2, O45630
      Conserved Domains (1) summary
      TIGR00845
      Location:6 → 975
      caca; sodium/calcium exchanger 1

    2. NM_072014.8 → NP_504415.2  Calx-beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504415.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYP3, O45630
      Conserved Domains (1) summary
      TIGR00845
      Location:6 → 925
      caca; sodium/calcium exchanger 1

    3. NM_001028473.5 → NP_001023644.1  Calx-beta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYP4, O45630
      Conserved Domains (1) summary
      TIGR00845
      Location:6 → 942
      caca; sodium/calcium exchanger 1

    4. NM_001028472.6 → NP_001023643.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7I7
      Conserved Domains (1) summary
      TIGR00845
      Location:1 → 397
      caca; sodium/calcium exchanger 1
    Nucleotide Protein
    Heading Accession and Version

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