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    nhr-20 Nuclear hormone receptor family member nhr-20 [ Caenorhabditis elegans ]

    Gene ID: 175546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-20
    Official Full Name
    Nuclear hormone receptor family member nhr-20
    Primary source
    WormBase:WBGene00003619
    Locus tag
    CELE_F43C1.4
    See related
    AllianceGenome:WB:WBGene00003619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including intestine; nervous system; pharyngeal-intestinal valve; reproductive system; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-20 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (4230436..4233219, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein phosphatase PHLPP-like protein Neighboring gene Mitogen-activated protein kinase mpk-1 Neighboring gene Uncharacterized protein Neighboring gene Coiled-coil domain-containing protein 25 Neighboring gene Large ribosomal subunit protein bL21m

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-20
    NP_497849.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4230436..4233219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065448.7 → NP_497849.1  Nuclear hormone receptor family member nhr-20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09565, Q9GTI6
      Conserved Domains (2) summary
      cd06157
      Location:244 → 428
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      smart00399
      Location:18 → 88
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09565.2

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