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    ucr-2.2 Peptidase M16 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181611, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ucr-2.2
    Official Full Name
    Peptidase M16 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00011679
    Locus tag
    CELE_T10B10.2
    See related
    AllianceGenome:WB:WBGene00011679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ucr-2.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (15173904..15178145)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferase Neighboring gene Secreted protein Neighboring gene Ion transport domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene PH domain-containing protein;RUN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode. Nomura H, et al. J Biochem, 2006 Jun. PMID 16788047
    2. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
    3. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
    4. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M16 N-terminal domain-containing protein
    NP_510521.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15173904..15178145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078120.5 → NP_510521.1  Peptidase M16 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22370
      Conserved Domains (3) summary
      COG0612
      Location:23 → 401
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:37 → 176
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:188 → 352
      Peptidase_M16_C; Peptidase M16 inactive domain
    Nucleotide Protein
    Heading Accession and Version

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