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    clec-66 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clec-66
    Official Full Name
    C-type lectin domain-containing protein
    Primary source
    WormBase:WBGene00009397
    Locus tag
    CELE_F35C5.9
    See related
    AllianceGenome:WB:WBGene00009397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clec-66 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (12904398..12906644)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Secreted protein Neighboring gene Protein sleepless Neighboring gene Knottin scorpion toxin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
    2. Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. Schulenburg H, et al. Immunobiology, 2008. PMID 18406370
    3. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
    4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    C-type lectin domain-containing protein
    NP_496746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12904398..12906644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064345.6 → NP_496746.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45445
      Conserved Domains (2) summary
      smart00034
      Location:243 → 382
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cd01477
      Location:36 → 223
      vWA_F09G8-8_type; VWA F09G8.8 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b ...
    Nucleotide Protein
    Heading Accession and Version

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