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    EBS1 Ebs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851787, updated on 9-Dec-2024

    Summary

    Official Symbol
    EBS1
    Official Full Name
    Ebs1p
    Primary source
    SGD:S000002614
    Locus tag
    YDR206W
    See related
    AllianceGenome:SGD:S000002614; FungiDB:YDR206W; VEuPathDB:YDR206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in DNA recombination; negative regulation of translation; and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in P-body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See EBS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (862054..864708)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquinone biosynthesis protein COQ4 Neighboring gene metal cation transporter MSC2 Neighboring gene DNA-binding transcriptional regulator UME6 Neighboring gene 1-phosphatidylinositol-4-phosphate 5-kinase

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function  
    enables telomerase RNA binding  
    enables telomeric DNA binding  
    Component Evidence Code Pubs
    located_in P-body PubMed 
    located_in P-body  
    located_in chromosome  
    located_in chromosome, telomeric region  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleus  
    part_of telomerase holoenzyme complex  

    General protein information

    Preferred Names
    Ebs1p
    NP_010492.3
    • Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      862054..864708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180514.3 → NP_010492.3  TPA: Ebs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010492.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI7, Q03466
      UniProtKB/TrEMBL
      C7GMZ3, N1P8E2
      Conserved Domains (2) summary
      pfam10373
      Location:228 → 516
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:80 → 214
      EST1; Telomerase activating protein Est1
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