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    PET8 Pet8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PET8
    Official Full Name
    Pet8p
    Primary source
    SGD:S000004948
    Locus tag
    YNL003C
    See related
    AllianceGenome:SGD:S000004948; FungiDB:YNL003C; VEuPathDB:YNL003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAM5
    Summary
    Enables S-adenosyl-L-methionine transmembrane transporter activity. Involved in S-adenosyl-L-methionine transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PET8 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (624975..625829, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL2 Neighboring gene mRNA-binding protein Neighboring gene Rlp7p Neighboring gene ribosome dissociation factor DOM34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine. Marobbio CM, et al. EMBO J, 2003 Nov 17. PMID 14609944, Free PMC Article
    2. Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae. Lalo D, et al. Yeast, 1994 Apr. PMID 7941739
    3. SLC25 Family Member Genetic Interactions Identify a Role for HEM25 in Yeast Electron Transport Chain Stability. Dufay JN, et al. G3 (Bethesda), 2017 Jun 7. PMID 28404662, Free PMC Article
    4. Characterization of mitochondrial carrier proteins of malaria parasite Plasmodium falciparum based on in vitro translation and reconstitution. Nozawa A, et al. Parasitol Int, 2020 Dec. PMID 32574727
    5. Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. el Moualij B, et al. Yeast, 1997 May. PMID 9178508

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosyl-L-methionine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosyl-L-methionine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables S-adenosyl-L-methionine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosyl-L-methionine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosyl-L-methionine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in S-adenosyl-L-methionine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in S-adenosyl-L-methionine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet8p
    NP_014395.3
    • S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      624975..625829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182842.3 → NP_014395.3  TPA: Pet8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014395.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1H4, P38921
      UniProtKB/TrEMBL
      A6ZS73, B3LPP1, C7GJE2, C8ZFM3, G2WL56, N1NY42
      Conserved Domains (1) summary
      PTZ00168
      Location:5 → 263
      PTZ00168; mitochondrial carrier protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38921.1

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