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    Marcks myristoylated alanine rich protein kinase C substrate [ Mus musculus (house mouse) ]

    Gene ID: 17118, updated on 9-Dec-2024

    Summary

    Official Symbol
    Marcksprovided by MGI
    Official Full Name
    myristoylated alanine rich protein kinase C substrateprovided by MGI
    Primary source
    MGI:MGI:96907
    See related
    Ensembl:ENSMUSG00000069662 AllianceGenome:MGI:96907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Macs; PKCSL
    Summary
    Enables several functions, including actin filament binding activity; calmodulin binding activity; and protein kinase C binding activity. Involved in several processes, including actin filament organization; nervous system development; and response to endoplasmic reticulum stress. Located in several cellular components, including cell cortex; cytoskeleton; and germinal vesicle. Is active in organelle. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; nerve; and sensory organ. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 127.7), whole brain E14.5 (RPKM 108.5) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Marcks in Genome Data Viewer
    Location:
    10 B1; 10 19.49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (37009239..37014922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (37133243..37138926, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 5 Neighboring gene predicted gene, 22554 Neighboring gene STARR-seq mESC enhancer starr_26331 Neighboring gene STARR-seq mESC enhancer starr_26332 Neighboring gene STARR-seq mESC enhancer starr_26333 Neighboring gene STARR-seq mESC enhancer starr_26336 Neighboring gene STARR-positive B cell enhancer mm9_chr10:36693912-36694212 Neighboring gene STARR-seq mESC enhancer starr_26337 Neighboring gene STARR-seq mESC enhancer starr_26339 Neighboring gene histone deacetylase 2 Neighboring gene STARR-seq mESC enhancer starr_26341 Neighboring gene STARR-seq mESC enhancer starr_26343 Neighboring gene STARR-seq mESC enhancer starr_26344 Neighboring gene RIKEN cDNA 5930403N24 gene Neighboring gene STARR-positive B cell enhancer ABC_E6829 Neighboring gene STARR-seq mESC enhancer starr_26346 Neighboring gene STARR-seq mESC enhancer starr_26347 Neighboring gene STARR-seq mESC enhancer starr_26350 Neighboring gene STARR-seq mESC enhancer starr_26352 Neighboring gene predicted gene, 26535 Neighboring gene STARR-seq mESC enhancer starr_26353 Neighboring gene predicted gene, 31202

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calmodulin binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bleb ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatoid body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic branch ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myristoylated alanine-rich C-kinase substrate
    Names
    80K protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008538.2NP_032564.1  myristoylated alanine-rich C-kinase substrate

      See identical proteins and their annotated locations for NP_032564.1

      Status: VALIDATED

      Source sequence(s)
      AC133944, BB569984, BC046601, M60474
      Consensus CDS
      CCDS23784.1
      UniProtKB/Swiss-Prot
      P26645
      UniProtKB/TrEMBL
      A0A0A1HAM8
      Related
      ENSMUSP00000090245.6, ENSMUST00000092584.6
      Conserved Domains (1) summary
      pfam02063
      Location:2305
      MARCKS; MARCKS family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      37009239..37014922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)