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    Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 109225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ms4a7provided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 7provided by MGI
    Primary source
    MGI:MGI:1918846
    See related
    Ensembl:ENSMUSG00000024672 AllianceGenome:MGI:1918846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CFFMA; CD20l4; 9130422I10Rik; A430103C15Rik
    Summary
    Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in body wall mesenchyme and embryo mesenchyme. Orthologous to human MS4A7 (membrane spanning 4-domains A7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 3.2), subcutaneous fat pad adult (RPKM 2.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ms4a7 in Genome Data Viewer
    Location:
    19 A; 19 8.43 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11298403..11313510, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11321039..11336146, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526L06 gene Neighboring gene STARR-seq mESC enhancer starr_45568 Neighboring gene membrane-spanning 4-domains, subfamily A, member 5 Neighboring gene STARR-seq mESC enhancer starr_45570 Neighboring gene membrane-spanning 4-domains, subfamily A, member 14 Neighboring gene membrane-spanning 4-domains, subfamily A, member 4A Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Zhou L, et al. Sci Transl Med, 2024 Mar 13. PMID 38478630
    2. CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Srivastava N, et al. Immunity, 2024 Jul 9. PMID 38754432,
    3. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Hammond TR, et al. Immunity, 2019 Jan 15. PMID 30471926, Free PMC Article
    4. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
    5. A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Rosin JM, et al. Dev Cell, 2021 May 3. PMID 33887203

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic danger signaling triggers TREM2[+] macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Title: Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane-spanning 4-domains subfamily A member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025610.4 → NP_001020781.1  membrane-spanning 4-domains subfamily A member 7 isoform b

      See identical proteins and their annotated locations for NP_001020781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, differs in the 5' UTR, and uses a downstream start codon compared to variant 3. This variant also lacks an alternate in-frame exon in the 5' coding region compared to variant 3. It encodes isoform b, which is shorter and has a distinct N-terminus compared to isoform c.
      Source sequence(s)
      AC134839, AK018686, AK046559, AK079888
      Consensus CDS
      CCDS29597.1
      UniProtKB/TrEMBL
      Q3U8S2, Q3UAR5, Q9D2W6
      Related
      ENSMUSP00000054830.3, ENSMUST00000056035.9
      Conserved Domains (1) summary
      pfam04103
      Location:47 → 185
      CD20; CD20-like family

    2. NM_001276398.1 → NP_001263327.1  membrane-spanning 4-domains subfamily A member 7 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC134839, AK079888, AK149890
      Consensus CDS
      CCDS70935.1
      UniProtKB/TrEMBL
      E9Q9V5, Q8BV59
      Related
      ENSMUSP00000025574.5, ENSMUST00000025574.11
      Conserved Domains (1) summary
      pfam04103
      Location:80 → 237
      CD20; CD20-like family

    3. NM_027836.6 → NP_082112.3  membrane-spanning 4-domains subfamily A member 7 isoform a

      See identical proteins and their annotated locations for NP_082112.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5' exon structure, differs in the 5' UTR and uses a downstream start codon compared to variant 3. It encodes isoform a which is shorter than isoform c.
      Source sequence(s)
      AC134839, AK046559, AK079888, AK151261
      Consensus CDS
      CCDS29598.1
      UniProtKB/TrEMBL
      Q3U8S2, Q3UAR5, Q99N04
      Related
      ENSMUSP00000064534.5, ENSMUST00000067532.11
      Conserved Domains (1) summary
      pfam04103
      Location:47 → 204
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11298403..11313510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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