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    Hrc histidine rich calcium binding protein [ Mus musculus (house mouse) ]

    Gene ID: 15464, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hrcprovided by MGI
    Official Full Name
    histidine rich calcium binding proteinprovided by MGI
    Primary source
    MGI:MGI:96226
    See related
    Ensembl:ENSMUSG00000038239 AllianceGenome:MGI:96226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATPase binding activity; calcium ion binding activity; and transmembrane transporter binding activity. Acts upstream of or within calcium ion homeostasis and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human HRC (histidine rich calcium binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 166.3) and mammary gland adult (RPKM 10.8) See more
    Orthologs
    NEW
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    Genomic context

    See Hrc in Genome Data Viewer
    Location:
    7 B3; 7 29.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44984693..44988397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45335269..45338973)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6543 Neighboring gene predicted gene, 39006 Neighboring gene transient receptor potential cation channel, subfamily M, member 4 Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E2237 Neighboring gene STARR-positive B cell enhancer ABC_E700 Neighboring gene STARR-positive B cell enhancer ABC_E11352 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sarcoplasmic reticulum histidine-rich calcium-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010473.2NP_034603.2  sarcoplasmic reticulum histidine-rich calcium-binding protein precursor

      See identical proteins and their annotated locations for NP_034603.2

      Status: VALIDATED

      Source sequence(s)
      AC150897, AF132218, AI322629
      Consensus CDS
      CCDS39950.1
      UniProtKB/TrEMBL
      G5E8J6, Q9QZV4
      Related
      ENSMUSP00000082459.5, ENSMUST00000085351.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44984693..44988397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)