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    Pfn3 profilin 3 [ Mus musculus (house mouse) ]

    Gene ID: 75477, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfn3provided by MGI
    Official Full Name
    profilin 3provided by MGI
    Primary source
    MGI:MGI:2178800
    See related
    Ensembl:ENSMUSG00000044444 AllianceGenome:MGI:2178800
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700012P12Rik
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in positive regulation of actin filament bundle assembly and regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Orthologous to human PFN3 (profilin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Pfn3 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55562501..55563045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55414688..55415232, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene lectin, mannose-binding 2 Neighboring gene STARR-positive B cell enhancer ABC_E7242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55471008-55471191 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55475647-55475848 Neighboring gene regulator of G-protein signaling 14 Neighboring gene STARR-positive B cell enhancer ABC_E4071 Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene STARR-seq mESC enhancer starr_34617 Neighboring gene STARR-positive B cell enhancer ABC_E8892 Neighboring gene coagulation factor XII (Hageman factor) Neighboring gene STARR-positive B cell enhancer ABC_E212 Neighboring gene STARR-positive B cell enhancer ABC_E4072 Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene microRNA 6943

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    profilin-3
    Names
    profilin III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029303.2NP_083579.1  profilin-3

      See identical proteins and their annotated locations for NP_083579.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048629
      Consensus CDS
      CCDS26545.1
      UniProtKB/Swiss-Prot
      Q9DAD6
      Related
      ENSMUSP00000054053.4, ENSMUST00000054146.5
      Conserved Domains (1) summary
      cd00148
      Location:3137
      PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55562501..55563045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)