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    Ep400 E1A binding protein p400 [ Mus musculus (house mouse) ]

    Gene ID: 75560, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ep400provided by MGI
    Official Full Name
    E1A binding protein p400provided by MGI
    Primary source
    MGI:MGI:1276124
    See related
    Ensembl:ENSMUSG00000029505 AllianceGenome:MGI:1276124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p400; mDomino; mKIAA1498; 1700020J09Rik
    Summary
    Predicted to enable chromatin binding activity and protein antigen binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Located in nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and trachea. Orthologous to human EP400 (E1A binding protein p400). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 36.8), thymus adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ep400 in Genome Data Viewer
    Location:
    5 F; 5 53.69 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110812239..110918583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110664373..110770927, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NOC4 like Neighboring gene DEAD box helicase 51 Neighboring gene microRNA 7026 Neighboring gene STARR-positive B cell enhancer ABC_E3599 Neighboring gene predicted gene, 22716 Neighboring gene predicted gene, 26079 Neighboring gene predicted gene, 22583 Neighboring gene STARR-positive B cell enhancer ABC_E2169 Neighboring gene predicted gene 15559 Neighboring gene pseudouridine synthase 1 Neighboring gene unc-51 like kinase 1 Neighboring gene STARR-seq mESC enhancer starr_13967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111239028-111239211

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein antigen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Swr1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E1A-binding protein p400
    Names
    domino homolog
    p400 kDa SWI2/SNF2-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029337.2NP_083613.2  E1A-binding protein p400 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS19529.1
      UniProtKB/Swiss-Prot
      E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54
      Related
      ENSMUSP00000049038.9, ENSMUST00000041558.15
      Conserved Domains (7) summary
      PHA03255
      Location:25112639
      PHA03255; BDLF3; Provisional
      smart00573
      Location:762833
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10731208
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10561336
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17761892
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:28223011
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal
    2. NM_173066.1NP_775089.1  E1A-binding protein p400 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also called mDomino-S, lacks an in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161348
      Consensus CDS
      CCDS51612.1
      UniProtKB/Swiss-Prot
      E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54
      Related
      ENSMUSP00000108055.3, ENSMUST00000112436.9
      Conserved Domains (7) summary
      PHA03255
      Location:24752603
      PHA03255; BDLF3; Provisional
      smart00573
      Location:726797
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:10371172
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:10201300
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:17401856
      Helicase_C; Helicase conserved C-terminal domain
      pfam03153
      Location:27862975
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam15790
      Location:1451
      EP400_N; E1A-binding protein p400, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110812239..110918583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)