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    CLASP1 cytoplasmic linker associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 23332, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CLASP1provided by HGNC
    Official Full Name
    cytoplasmic linker associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17088
    See related
    Ensembl:ENSG00000074054 MIM:605852; AllianceGenome:HGNC:17088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAST1
    Summary
    CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CLASP1 in Genome Data Viewer
    Location:
    2q14.2-q14.3
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (121337776..121649462, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (121773062..122084742, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (122095352..122407038, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121974845-121975346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122003829-122004330 Neighboring gene transcription factor CP2 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122091915-122092848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122094177-122094762 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122109698-122109870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16463 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122140378-122140878 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:122187059-122188258 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122205649-122205872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16465 Neighboring gene CLASP1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122405992-122406620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122406621-122407247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16469 Neighboring gene NIFK antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:122437634-122438136 Neighboring gene ribosomal protein L12 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122457551-122458050 Neighboring gene uncharacterized LOC124906186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment. Aonuma M, et al. Cell Struct Funct, 2005. PMID 16145243
    2. Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process. Zhao X, et al. Cell Microbiol, 2013 Apr. PMID 23107073, Free PMC Article
    3. How do kinetochores CLASP dynamic microtubules? Maiato H, et al. Cell Cycle, 2003 Nov-Dec. PMID 14504462
    4. Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells. Miller PM, et al. Nat Cell Biol, 2009 Sep. PMID 19701196, Free PMC Article
    5. PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis. Liu J, et al. J Biol Chem, 2009 Aug 21. PMID 19561070, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential regulation of single microtubules and bundles by a three-protein module.
      Title: Differential regulation of single microtubules and bundles by a three-protein module.
    2. Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions.
      Title: Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
    3. catastrophe inhibition by SLAIN2 and CLASP1 supports mesenchymal cell shape in soft 3D matrices by enabling microtubules to perform a load-bearing function.
      Title: Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.
    4. Acute silencing of CLASP1, a +TIP that participates in microtubule stabilization at the cell periphery, impairs trypomastigote internalization without diminishing the capacity for calcium-regulated lysosome exocytosis.
      Title: Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process.
    5. Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.
      Title: CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.
    6. our data suggest a model for mitotic spindle positioning in which RanGTP and CLASP1 cooperate to align the spindle along the long axis of the dividing cell.
      Title: RanGTP and CLASP1 cooperate to position the mitotic spindle.
    7. findings highlight the common mechanistic use of TOG domains in XMAP215 and CLASP families to regulate MT dynamics and suggest that differential TOG domain architecture may confer distinct functions to these critical cytoskeletal regulators
      Title: A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.
    8. The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP1, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).
      Title: Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.
    9. Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells.
      Title: CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
    10. Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis.
      Title: MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2022-12-13)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2022-12-13)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33821, FLJ41222, KIAA0622, MGC131895, DKFZp686D1968, DKFZp686H2039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinetochore binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinetochore binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of spindle orientation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule organizing center organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosomal corona IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLIP-associating protein 1
    Names
    multiple asters 1
    multiple asters homolog 1
    protein Orbit homolog 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142273.2 → NP_001135745.1  CLIP-associating protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001135745.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes two alternate in-frame exons but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AJ288057, BC032563, BC132723, BE328429
      UniProtKB/TrEMBL
      F8WA11
      Related
      ENSP00000389372.3, ENST00000455322.7
      Conserved Domains (4) summary
      PHA03307
      Location:565 → 723
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    2. NM_001142274.2 → NP_001135746.1  CLIP-associating protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001135746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate in-frame exon but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AJ288057, BC032563, BC112940, BE328429
      Consensus CDS
      CCDS92851.1
      UniProtKB/TrEMBL
      A0A8V8TQK9
      Related
      ENSP00000386442.3, ENST00000409078.8
      Conserved Domains (4) summary
      PHA03307
      Location:568 → 715
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    3. NM_001207051.2 → NP_001193980.1  CLIP-associating protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001193980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has several differences in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AJ288057, BC032563, BC144107, BE328429
      Consensus CDS
      CCDS92854.1
      UniProtKB/TrEMBL
      F8WA11
      Related
      ENSP00000441625.1, ENST00000541377.5
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    4. NM_001378003.1 → NP_001364932.1  CLIP-associating protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC012447, AC013399, AC018737, AC079449
      UniProtKB/TrEMBL
      F8WA11
      Conserved Domains (4) summary
      PHA03307
      Location:568 → 715
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    5. NM_001378004.1 → NP_001364933.1  CLIP-associating protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC012447, AC013399, AC018737, AC079449
      UniProtKB/TrEMBL
      F8WA11
      Conserved Domains (4) summary
      PHA03307
      Location:565 → 723
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    6. NM_001378005.1 → NP_001364934.1  CLIP-associating protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC012447, AC013399, AC018737, AC079449
      UniProtKB/TrEMBL
      F8WA11
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:324 → 537
      CLASP_N; CLASP N terminal

    7. NM_001395891.1 → NP_001382820.1  CLIP-associating protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC012447, AC013399, AC018737, AC079449
      Consensus CDS
      CCDS92853.1
      UniProtKB/TrEMBL
      A0A8V8TLP7, A0A8V8TQK9
      Related
      ENSP00000512981.1, ENST00000696935.1
      Conserved Domains (2) summary
      PHA03307
      Location:564 → 806
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    8. NM_015282.3 → NP_056097.1  CLIP-associating protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF347693, AJ288057, BC032563, BE328429
      Consensus CDS
      CCDS92852.1
      UniProtKB/Swiss-Prot
      A2RU21, B7ZLX3, F5GWS0, O75118, Q2KHQ9, Q5H9P0, Q7Z460, Q8N5B8, Q9BQT5
      UniProtKB/TrEMBL
      A0A8V8TQK9
      Related
      ENSP00000263710.4, ENST00000263710.8
      Conserved Domains (3) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      121337776..121649462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443792.1 → XP_047299748.1  CLIP-associating protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Related
      ENSP00000515167.1, ENST00000700755.1

    2. XM_047443782.1 → XP_047299738.1  CLIP-associating protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQK9

    3. XM_006712383.2 → XP_006712446.1  CLIP-associating protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8V8TQK9, A0A8V8TRF6
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:566 → 726
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    4. XM_047443791.1 → XP_047299747.1  CLIP-associating protein 1 isoform X20

      UniProtKB/TrEMBL
      F8WA11

    5. XM_047443781.1 → XP_047299737.1  CLIP-associating protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQK9

    6. XM_006712382.2 → XP_006712445.1  CLIP-associating protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam05956
      Location:566 → 726
      APC_basic; APC basic domain
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    7. XM_047443796.1 → XP_047299752.1  CLIP-associating protein 1 isoform X27

      UniProtKB/TrEMBL
      A0A8V8TQK9

    8. XM_047443795.1 → XP_047299751.1  CLIP-associating protein 1 isoform X26

      UniProtKB/TrEMBL
      A0A8V8TQK9

    9. XM_047443789.1 → XP_047299745.1  CLIP-associating protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Related
      ENSP00000515166.1, ENST00000700754.1

    10. XM_011510849.2 → XP_011509151.1  CLIP-associating protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Conserved Domains (2) summary
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    11. XM_011510848.2 → XP_011509150.1  CLIP-associating protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Conserved Domains (2) summary
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]

    12. XM_047443786.1 → XP_047299742.1  CLIP-associating protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TQK9

    13. XM_047443788.1 → XP_047299744.1  CLIP-associating protein 1 isoform X17

      UniProtKB/TrEMBL
      F8WA11

    14. XM_047443778.1 → XP_047299734.1  CLIP-associating protein 1 isoform X3

      UniProtKB/TrEMBL
      F8WA11

    15. XM_017003673.2 → XP_016859162.1  CLIP-associating protein 1 isoform X12

      UniProtKB/TrEMBL
      F8WA11
      Conserved Domains (4) summary
      PHA03307
      Location:565 → 723
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    16. XM_047443784.1 → XP_047299740.1  CLIP-associating protein 1 isoform X11

      UniProtKB/TrEMBL
      F8WA11

    17. XM_047443787.1 → XP_047299743.1  CLIP-associating protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8V8TQK9

    18. XM_006712381.2 → XP_006712444.1  CLIP-associating protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TQK9
      Conserved Domains (4) summary
      sd00044
      Location:93 → 120
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam11179
      Location:572 → 723
      DUF2967; Protein of unknown function (DUF2967)
      pfam12348
      Location:326 → 537
      CLASP_N; CLASP N terminal

    19. XM_047443783.1 → XP_047299739.1  CLIP-associating protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQK9

    20. XM_047443785.1 → XP_047299741.1  CLIP-associating protein 1 isoform X13

      UniProtKB/TrEMBL
      F8WA11

    21. XM_047443797.1 → XP_047299753.1  CLIP-associating protein 1 isoform X28

      UniProtKB/TrEMBL
      F8WA11

    22. XM_047443780.1 → XP_047299736.1  CLIP-associating protein 1 isoform X5

      UniProtKB/TrEMBL
      F8WA11

    23. XM_047443779.1 → XP_047299735.1  CLIP-associating protein 1 isoform X4

      UniProtKB/TrEMBL
      F8WA11

    24. XM_017003665.2 → XP_016859154.1  CLIP-associating protein 1 isoform X2

      UniProtKB/TrEMBL
      F8WA11

    25. XM_047443777.1 → XP_047299733.1  CLIP-associating protein 1 isoform X1

      UniProtKB/TrEMBL
      F8WA11

    26. XM_047443793.1 → XP_047299749.1  CLIP-associating protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8V8TQK9

    27. XM_017003682.3 → XP_016859171.1  CLIP-associating protein 1 isoform X23

      UniProtKB/TrEMBL
      B7Z4E5
      Related
      ENSP00000400562.3, ENST00000452274.7
      Conserved Domains (2) summary
      pfam12348
      Location:94 → 305
      CLASP_N; CLASP N terminal
      sd00044
      Location:604 → 631
      HEAT; HEAT repeat [structural motif]

    28. XM_047443794.1 → XP_047299750.1  CLIP-associating protein 1 isoform X24

    29. XM_017003690.2 → XP_016859179.1  CLIP-associating protein 1 isoform X25

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      121773062..122084742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341142.1 → XP_054197117.1  CLIP-associating protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8V8TQK9

    2. XM_054341130.1 → XP_054197105.1  CLIP-associating protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQK9

    3. XM_054341141.1 → XP_054197116.1  CLIP-associating protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8V8TQK9, A0A8V8TRF6

    4. XM_054341140.1 → XP_054197115.1  CLIP-associating protein 1 isoform X20

      UniProtKB/TrEMBL
      F8WA11

    5. XM_054341129.1 → XP_054197104.1  CLIP-associating protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQK9

    6. XM_054341138.1 → XP_054197113.1  CLIP-associating protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8V8TQK9

    7. XM_054341148.1 → XP_054197123.1  CLIP-associating protein 1 isoform X27

      UniProtKB/TrEMBL
      A0A8V8TQK9

    8. XM_054341147.1 → XP_054197122.1  CLIP-associating protein 1 isoform X26

      UniProtKB/TrEMBL
      A0A8V8TQK9

    9. XM_054341139.1 → XP_054197114.1  CLIP-associating protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A8V8TQK9

    10. XM_054341133.1 → XP_054197108.1  CLIP-associating protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQK9

    11. XM_054341132.1 → XP_054197107.1  CLIP-associating protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQK9

    12. XM_054341137.1 → XP_054197112.1  CLIP-associating protein 1 isoform X17

      UniProtKB/TrEMBL
      F8WA11

    13. XM_054341126.1 → XP_054197101.1  CLIP-associating protein 1 isoform X3

      UniProtKB/TrEMBL
      F8WA11

    14. XM_054341134.1 → XP_054197109.1  CLIP-associating protein 1 isoform X12

      UniProtKB/TrEMBL
      F8WA11

    15. XM_054341136.1 → XP_054197111.1  CLIP-associating protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8V8TQK9

    16. XM_054341135.1 → XP_054197110.1  CLIP-associating protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TQK9

    17. XM_054341131.1 → XP_054197106.1  CLIP-associating protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQK9

    18. XM_054341149.1 → XP_054197124.1  CLIP-associating protein 1 isoform X28

      UniProtKB/TrEMBL
      F8WA11

    19. XM_054341128.1 → XP_054197103.1  CLIP-associating protein 1 isoform X5

      UniProtKB/TrEMBL
      F8WA11

    20. XM_054341127.1 → XP_054197102.1  CLIP-associating protein 1 isoform X4

      UniProtKB/TrEMBL
      F8WA11

    21. XM_054341125.1 → XP_054197100.1  CLIP-associating protein 1 isoform X2

      UniProtKB/TrEMBL
      F8WA11

    22. XM_054341143.1 → XP_054197118.1  CLIP-associating protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8V8TQK9

    23. XM_054341124.1 → XP_054197099.1  CLIP-associating protein 1 isoform X1

      UniProtKB/TrEMBL
      F8WA11

    24. XM_054341144.1 → XP_054197119.1  CLIP-associating protein 1 isoform X23

      UniProtKB/TrEMBL
      B7Z4E5

    25. XM_054341145.1 → XP_054197120.1  CLIP-associating protein 1 isoform X24

    26. XM_054341146.1 → XP_054197121.1  CLIP-associating protein 1 isoform X25

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z460.1 GenPept UniProtKB/Swiss-Prot:Q7Z460

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