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    LOS1 Ran GTPase-binding protein LOS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LOS1
    Official Full Name
    Ran GTPase-binding protein LOS1
    Primary source
    SGD:S000001688
    Locus tag
    YKL205W
    See related
    AllianceGenome:SGD:S000001688; FungiDB:YKL205W; VEuPathDB:YKL205W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small GTPase binding activity. Involved in tRNA re-export from nucleus. Located in cytoplasm and nuclear matrix. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LOS1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (50051..53353)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Emc3p Neighboring gene Add66p Neighboring gene Eap1p Neighboring gene phosphatidylinositol kinase-related protein kinase TOR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix. Shen WC, et al. J Biol Chem, 1993 Sep 15. PMID 8366091
    2. The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae. Steiner-Mosonyi M, et al. Biochem J, 2004 Mar 15. PMID 14640976, Free PMC Article
    3. PAUSED encodes the Arabidopsis exportin-t ortholog. Hunter CA, et al. Plant Physiol, 2003 Aug. PMID 12913168, Free PMC Article
    4. Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing. Karkusiewicz I, et al. J Biol Chem, 2011 Nov 11. PMID 21940626, Free PMC Article
    5. Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing. Hurt DJ, et al. Mol Cell Biol, 1987 Mar. PMID 3031485, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. merely fivefold overexpression of Mex67-Mtr2 can substitute for Los1 in los1Delta cells
      Title: Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.
    2. the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging.
      Title: A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
    3. Subcellular distributions of Msn5 and Los1 are altered upon glucose deprivation but not amino acid deprivation.
      Title: Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport.
    4. Cex1p recruits Rna1p from the cytoplasm to the nuclear pore complex and facilitates Rna1p activation of the GTPase activity of Gsp1p by enabling Rna1p to gain access to Gsp1p-GTP bound to the Los1p-tRNA-Gsp1p-GTP export complex.
      Title: Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA re-export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA re-export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase-binding protein LOS1
    NP_012717.1
    • Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      50051..53353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179770.1 → NP_012717.1  TPA: Ran GTPase-binding protein LOS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWZ8, P33418
      UniProtKB/TrEMBL
      G2WHI9, N1P0R2
      Conserved Domains (2) summary
      COG5101
      Location:2 → 379
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:102 → 274
      Xpo1; Exportin 1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33418.1

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