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    Metap1 methionyl aminopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75624, updated on 9-Dec-2024

    Summary

    Official Symbol
    Metap1provided by MGI
    Official Full Name
    methionyl aminopeptidase 1provided by MGI
    Primary source
    MGI:MGI:1922874
    See related
    Ensembl:ENSMUSG00000005813 AllianceGenome:MGI:1922874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0094; 1700029C17Rik
    Summary
    Enables aminopeptidase activity. Involved in protein maturation. Predicted to be located in cytosolic ribosome. Predicted to be active in cytosol. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 27.6), CNS E11.5 (RPKM 21.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Metap1 in Genome Data Viewer
    Location:
    3 G3; 3 64.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138164721..138195143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138458960..138489382, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide Neighboring gene STARR-seq mESC enhancer starr_09108 Neighboring gene STARR-positive B cell enhancer ABC_E6139 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene predicted gene, 32553 Neighboring gene STARR-positive B cell enhancer ABC_E1269 Neighboring gene microRNA 1956 Neighboring gene eukaryotic translation initiation factor 4E Neighboring gene STARR-seq mESC enhancer starr_09110 Neighboring gene predicted gene, 29762

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0094

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables initiator methionyl aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methionine aminopeptidase 1
    Names
    MAP 1
    Putative methionine aminopeptidase 1 (MetAP 1) (Peptidase M 1)
    metAP 1
    peptidase M 1
    NP_780433.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175224.4NP_780433.1  methionine aminopeptidase 1

      Status: PROVISIONAL

      Source sequence(s)
      AC079845
      Consensus CDS
      CCDS17869.1
      UniProtKB/Swiss-Prot
      Q8BP48
      UniProtKB/TrEMBL
      Q4VAA9
      Related
      ENSMUSP00000029804.9, ENSMUST00000029804.13
      Conserved Domains (1) summary
      cl00279
      Location:14382
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138164721..138195143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)