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    Vamp4 vesicle-associated membrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 53330, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vamp4provided by MGI
    Official Full Name
    vesicle-associated membrane protein 4provided by MGI
    Primary source
    MGI:MGI:1858730
    See related
    Ensembl:ENSMUSG00000026696 AllianceGenome:MGI:1858730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vamp-4; D1Ertd147e
    Summary
    Acts upstream of or within Golgi to plasma membrane protein transport; cellular response to type II interferon; and regulation of Golgi to plasma membrane protein transport. Located in phagocytic vesicle and trans-Golgi network. Part of SNARE complex. Is active in presynaptic endosome membrane. Is expressed in cerebellum layer; gonad; and ventral tegmental area. Orthologous to human VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 8.9), cortex adult (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vamp4 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162398084..162426651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162570515..162599082)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5839 Neighboring gene STARR-positive B cell enhancer ABC_E7767 Neighboring gene STARR-positive B cell enhancer ABC_E10051 Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin Neighboring gene myocilin opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vesicle-associated membrane protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347125.1NP_001334054.1  vesicle-associated membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS83616.1
      UniProtKB/Swiss-Prot
      O70480, Q9D095
      Related
      ENSMUSP00000115133.2, ENSMUST00000150040.8
      Conserved Domains (1) summary
      cd15869
      Location:50116
      R-SNARE_VAMP4; SNARE motif of VAMP4
    2. NM_001356526.1NP_001343455.1  vesicle-associated membrane protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS15421.1
      UniProtKB/TrEMBL
      Q8BSN6
      Related
      ENSMUSP00000121977.2, ENSMUST00000132158.8
      Conserved Domains (1) summary
      cd15869
      Location:50116
      R-SNARE_VAMP4; SNARE motif of VAMP4
    3. NM_001356527.1NP_001343456.1  vesicle-associated membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS83616.1
      UniProtKB/Swiss-Prot
      O70480, Q9D095
      Related
      ENSMUSP00000116376.2, ENSMUST00000135241.8
      Conserved Domains (1) summary
      cd15869
      Location:50116
      R-SNARE_VAMP4; SNARE motif of VAMP4
    4. NM_016796.3NP_058076.2  vesicle-associated membrane protein 4 isoform 1

      See identical proteins and their annotated locations for NP_058076.2

      Status: VALIDATED

      Source sequence(s)
      AK031151
      Consensus CDS
      CCDS15421.1
      UniProtKB/TrEMBL
      Q8BSN6
      Related
      ENSMUSP00000051544.5, ENSMUST00000050010.11
      Conserved Domains (1) summary
      cd15869
      Location:50116
      R-SNARE_VAMP4; SNARE motif of VAMP4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162398084..162426651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)