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    Pnpla8 patatin-like phospholipase domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 67452, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnpla8provided by MGI
    Official Full Name
    patatin-like phospholipase domain containing 8provided by MGI
    Primary source
    MGI:MGI:1914702
    See related
    Ensembl:ENSMUSG00000036257 AllianceGenome:MGI:1914702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ipla2(gamma); 1200006O19Rik
    Summary
    Enables calcium-independent phospholipase A2 activity. Involved in cardiolipin metabolic process; regulation of cellular response to oxidative stress; and triglyceride homeostasis. Located in mitochondrion and peroxisome. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 9.4), frontal lobe adult (RPKM 9.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pnpla8 in Genome Data Viewer
    Location:
    12 B2; 12 20.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (44315916..44362718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (44269132..44315936)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32028 Neighboring gene microRNA 5627 Neighboring gene STARR-positive B cell enhancer ABC_E9857 Neighboring gene nuclear assembly factor 1 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8482 Neighboring gene STARR-positive B cell enhancer ABC_E11510 Neighboring gene STARR-positive B cell enhancer mm9_chr12:45393214-45393515 Neighboring gene STARR-seq mESC enhancer starr_32032 Neighboring gene neuronal cell adhesion molecule Neighboring gene VISTA enhancer mm16 Neighboring gene STARR-seq mESC enhancer starr_32034 Neighboring gene zinc finger, BED domain containing 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-independent phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-independent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arachidonate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiolipin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiolipin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylethanolamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium-independent phospholipase A2-gamma
    Names
    iPLA2-gamma
    intracellular membrane-associated calcium-independent phospholipase A2 gamma
    patatin-like phospholipase domain-containing protein 8
    NP_080440.2
    XP_006516237.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026164.2NP_080440.2  calcium-independent phospholipase A2-gamma

      See identical proteins and their annotated locations for NP_080440.2

      Status: VALIDATED

      Source sequence(s)
      AB044139, AK033938, AK145776, CJ112890
      Consensus CDS
      CCDS36436.1
      UniProtKB/Swiss-Prot
      Q3TH33, Q8K1N1, Q8VEC0, Q9DC20
      UniProtKB/TrEMBL
      E9QAC9
      Related
      ENSMUSP00000043286.9, ENSMUST00000043082.16
      Conserved Domains (1) summary
      cd07211
      Location:429735
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      44315916..44362718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516174.5XP_006516237.1  calcium-independent phospholipase A2-gamma isoform X1

      UniProtKB/TrEMBL
      E9QAC9
      Conserved Domains (1) summary
      cd07211
      Location:429685
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8