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    Fcnb ficolin B [ Mus musculus (house mouse) ]

    Gene ID: 14134, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fcnbprovided by MGI
    Official Full Name
    ficolin Bprovided by MGI
    Primary source
    MGI:MGI:1341158
    See related
    Ensembl:ENSMUSG00000026835 AllianceGenome:MGI:1341158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcn2
    Summary
    Enables sialic acid binding activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be located in plasma membrane. Predicted to be part of serine-type endopeptidase complex. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in bone marrow; embryo; liver; spleen; and thymus. Orthologous to several human genes including FCN1 (ficolin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 15.1), liver E14 (RPKM 5.5) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fcnb in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27966491..27974921, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28076479..28084910, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39777 Neighboring gene collagen, type V, alpha 1 Neighboring gene predicted gene 13372 Neighboring gene RIKEN cDNA F730016J06 gene Neighboring gene STARR-seq mESC enhancer starr_04018 Neighboring gene olfactomedin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC130137, MGC130138

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate derivative binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate derivative binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mannan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sialic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement activation, lectin pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of opsonization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in recognition of apoptotic cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine-type endopeptidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine-type endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ficolin-2
    Names
    L-ficolin
    collagen/fibrinogen domain-containing protein 2
    ficolin-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010190.1NP_034320.1  ficolin-2 precursor

      See identical proteins and their annotated locations for NP_034320.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107220
      Consensus CDS
      CCDS15832.1
      UniProtKB/Swiss-Prot
      O70497, Q3KNL6
      Related
      ENSMUSP00000028179.9, ENSMUST00000028179.15
      Conserved Domains (2) summary
      pfam01391
      Location:4095
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:103312
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      27966491..27974921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497676.5XP_006497739.1  ficolin-2 isoform X1

      Conserved Domains (2) summary
      pfam01391
      Location:4095
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:103238
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...