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    Zdhhc12 zinc finger, DHHC domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 66220, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zdhhc12provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 12provided by MGI
    Primary source
    MGI:MGI:1913470
    See related
    Ensembl:ENSMUSG00000015335 AllianceGenome:MGI:1913470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190004A01Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in gephyrin clustering involved in postsynaptic density assembly; peptidyl-L-cysteine S-palmitoylation; and positive regulation of GABAergic synaptic transmission. Located in Golgi apparatus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 53.0), testis adult (RPKM 52.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Zdhhc12 in Genome Data Viewer
    Location:
    2 B; 2 21.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29980956..29983647, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30090943..30093638, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynein 2 intermediate chain 2 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene protein kinase N3 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC12
    Names
    DHHC domain-containing cysteine-rich protein 12
    DHHC-12
    probable palmitoyltransferase ZDHHC12
    zinc finger DHHC domain-containing protein 12
    NP_001032851.1
    NP_079704.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037762.1NP_001032851.1  palmitoyltransferase ZDHHC12 isoform b

      See identical proteins and their annotated locations for NP_001032851.1

      Status: VALIDATED

      Source sequence(s)
      AK013074, AK087676, BX005298
      Consensus CDS
      CCDS15868.1
      UniProtKB/Swiss-Prot
      Q8VC90, Q9CZ24, Q9D0T6
      Related
      ENSMUSP00000099929.5, ENSMUST00000102865.11
      Conserved Domains (1) summary
      pfam01529
      Location:123217
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_025428.2NP_079704.2  palmitoyltransferase ZDHHC12 isoform a

      See identical proteins and their annotated locations for NP_079704.2

      Status: VALIDATED

      Source sequence(s)
      AK013074, AK087676, BX005298, BY249117
      Consensus CDS
      CCDS15869.1
      UniProtKB/Swiss-Prot
      Q8VC90
      Related
      ENSMUSP00000080521.7, ENSMUST00000081838.7
      Conserved Domains (1) summary
      pfam01529
      Location:137231
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29980956..29983647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)