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    Fbxo22 F-box protein 22 [ Mus musculus (house mouse) ]

    Gene ID: 71999, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxo22provided by MGI
    Official Full Name
    F-box protein 22provided by MGI
    Primary source
    MGI:MGI:1926014
    See related
    Ensembl:ENSMUSG00000032309 AllianceGenome:MGI:1926014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610033L19Rik; 1600016C16Rik
    Summary
    Acts upstream of or within several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.5), CNS E11.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxo22 in Genome Data Viewer
    Location:
    9 B; 9 29.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55116219..55131717)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55208935..55224433)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene ubiquitin-conjugating enzyme E2Q family member 2 Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene neuregulin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene transmembrane protein 266

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028049.2NP_082325.2  F-box only protein 22

      See identical proteins and their annotated locations for NP_082325.2

      Status: VALIDATED

      Source sequence(s)
      AK005473, AW490772, CJ078336
      Consensus CDS
      CCDS23202.2
      UniProtKB/Swiss-Prot
      Q78JE5
      Related
      ENSMUSP00000034859.9, ENSMUST00000034859.15
      Conserved Domains (2) summary
      pfam10442
      Location:265363
      FIST_C; FIST C domain
      pfam12937
      Location:2757
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55116219..55131717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511459.4XP_006511522.1  F-box only protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006511522.1

      UniProtKB/TrEMBL
      Q3V492
      Related
      ENSMUSP00000117106.2, ENSMUST00000146201.8
      Conserved Domains (1) summary
      COG4398
      Location:195294
      FIST; Small ligand-binding sensory domain FIST [Signal transduction mechanisms]