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    Dctn4 dynactin 4 [ Mus musculus (house mouse) ]

    Gene ID: 67665, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dctn4provided by MGI
    Official Full Name
    dynactin 4provided by MGI
    Primary source
    MGI:MGI:1914915
    See related
    Ensembl:ENSMUSG00000024603 AllianceGenome:MGI:1914915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p62; 1110001K06Rik; 4930547K17Rik; C130039E17Rik
    Summary
    Predicted to be located in cytoskeleton; focal adhesion; and kinetochore. Predicted to be part of cytoplasmic dynein complex and dynactin complex. Is expressed in cerebral cortex. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 20.0), whole brain E14.5 (RPKM 18.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dctn4 in Genome Data Viewer
    Location:
    18 D3; 18 34.36 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60659226..60691838)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60526154..60558766)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44715 Neighboring gene small integral membrane protein 3 Neighboring gene predicted gene, 46628 Neighboring gene STARR-positive B cell enhancer ABC_E9978 Neighboring gene predicted gene, 52358 Neighboring gene RNA binding motif protein 22 Neighboring gene myozenin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynactin subunit 4
    Names
    dynactin subunit p62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357462.1NP_001344391.1  dynactin subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC135638, AK034292, AK160813, BB856653, CJ308131
      Consensus CDS
      CCDS89246.1
      UniProtKB/Swiss-Prot
      Q8CBY8, Q923A0, Q9D4X0
      Related
      ENSMUSP00000153008.2, ENSMUST00000223984.2
      Conserved Domains (1) summary
      pfam05502
      Location:23348
      Dynactin_p62; Dynactin p62 family
    2. NM_026302.4NP_080578.1  dynactin subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_080578.1

      Status: VALIDATED

      Source sequence(s)
      AC135638, AK160813, AK163240, BB856653, CJ308131
      Consensus CDS
      CCDS37832.1
      UniProtKB/TrEMBL
      Q3TQY2
      Related
      ENSMUSP00000025505.6, ENSMUST00000025505.7
      Conserved Domains (1) summary
      pfam05502
      Location:23341
      Dynactin_p62; Dynactin p62 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60659226..60691838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)