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    Elp4 elongator acetyltransferase complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 77766, updated on 9-Dec-2024

    Summary

    Official Symbol
    Elp4provided by MGI
    Official Full Name
    elongator acetyltransferase complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1925016
    See related
    Ensembl:ENSMUSG00000027167 AllianceGenome:MGI:1925016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paxneb; A330107A17Rik
    Summary
    Predicted to enable phosphorylase kinase regulator activity. Predicted to contribute to RNA polymerase II complex binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Predicted to be located in nucleoplasm. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including eye and telencephalon. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 3.0), CNS E11.5 (RPKM 2.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Elp4 in Genome Data Viewer
    Location:
    2 E3; 2 55.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (105527665..105734909, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (105697320..105904564, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene paired box 6 opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05312 Neighboring gene Pax6 upstream regulatory region Neighboring gene predicted gene, 35946 Neighboring gene STARR-seq mESC enhancer starr_05314 Neighboring gene enhancer in intron 4 of Pax6 Neighboring gene enhancer region in intron 7 of Pax6 Neighboring gene Pax6 upstream antisense RNA Neighboring gene STARR-seq mESC enhancer starr_05317 Neighboring gene paired box 6 Neighboring gene RB enhancer downstream of Pax6 Neighboring gene Pax6 downstream regulatory region Neighboring gene STARR-seq mESC enhancer starr_05318 Neighboring gene STARR-seq mESC enhancer starr_05319 Neighboring gene STARR-positive B cell enhancer ABC_E639 Neighboring gene IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:105843384-105843567 Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene doublecortin domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorylase kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorylase kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of elongator holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    elongator complex protein 4
    Names
    PAX6 neighbor gene protein
    elongation protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023876.4NP_076365.2  elongator complex protein 4

      See identical proteins and their annotated locations for NP_076365.2

      Status: VALIDATED

      Source sequence(s)
      AA914716, AK037104, AK039758, AK042006, AK140480, AK168964
      Consensus CDS
      CCDS16500.1
      UniProtKB/Swiss-Prot
      Q8BGM1, Q8BVB1, Q8BZN8, Q9CTR2, Q9ER73
      Related
      ENSMUSP00000116575.2, ENSMUST00000122965.8
      Conserved Domains (1) summary
      pfam05625
      Location:28421
      PAXNEB; PAXNEB protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      105527665..105734909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)