U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kyat1 kynurenine aminotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 70266, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kyat1provided by MGI
    Official Full Name
    kynurenine aminotransferase 1provided by MGI
    Primary source
    MGI:MGI:1917516
    See related
    Ensembl:ENSMUSG00000039648 AllianceGenome:MGI:1917516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtk; Kat1; KatI; Ccbl1; 2010009K05Rik
    Summary
    Predicted to enable cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; and transaminase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 63.7), liver E18 (RPKM 19.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kyat1 in Genome Data Viewer
    Location:
    2 B; 2 21.31 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30075136..30096307, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30185124..30206295, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804 Neighboring gene STARR-seq mESC enhancer starr_04091 Neighboring gene leucine rich repeat containing 8A VRAC subunit A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-S-conjugate beta-lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamine-phenylpyruvate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamine-phenylpyruvate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kynurenine-oxoglutarate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kynurenine-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kynurenine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kynurenine--oxoglutarate transaminase 1
    Names
    cysteine conjugate-beta lyase 1
    cysteine-S-conjugate beta-lyase
    cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
    glutamine transaminase K
    glutamine--phenylpyruvate transaminase
    kynurenine aminotransferase I
    kynurenine--oxoglutarate transaminase I
    NP_001343403.1
    NP_001343404.1
    NP_765992.2
    XP_006498378.1
    XP_006498380.1
    XP_030107921.1
    XP_036018454.1
    XP_036018455.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356474.2NP_001343403.1  kynurenine--oxoglutarate transaminase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL845258
      Consensus CDS
      CCDS15874.1
      UniProtKB/Swiss-Prot
      Q8BTY1, Q8BY27
      UniProtKB/TrEMBL
      A2AQY9, Q05CI8
      Related
      ENSMUSP00000038612.4, ENSMUST00000044038.10
      Conserved Domains (1) summary
      cl27741
      Location:23420
      Aminotran_1_2; Aminotransferase class I and II
    2. NM_001356475.2NP_001343404.1  kynurenine--oxoglutarate transaminase 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL845258
      UniProtKB/TrEMBL
      A2AQY9
      Related
      ENSMUST00000148555.8
      Conserved Domains (1) summary
      PRK08912
      Location:3362
      PRK08912; aminotransferase
    3. NM_001434246.1NP_001421175.1  kynurenine--oxoglutarate transaminase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845258
      UniProtKB/TrEMBL
      A2AQY9
    4. NM_001434247.1NP_001421176.1  kynurenine--oxoglutarate transaminase 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845258
    5. NM_172404.4NP_765992.2  kynurenine--oxoglutarate transaminase 1 isoform a

      See identical proteins and their annotated locations for NP_765992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL845258
      Consensus CDS
      CCDS15874.1
      UniProtKB/Swiss-Prot
      Q8BTY1, Q8BY27
      UniProtKB/TrEMBL
      A2AQY9, Q05CI8
      Related
      ENSMUSP00000109293.3, ENSMUST00000113663.9
      Conserved Domains (1) summary
      cl27741
      Location:23420
      Aminotran_1_2; Aminotransferase class I and II

    RNA

    1. NR_197769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845258
    2. NR_197770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845258

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30075136..30096307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498315.2XP_006498378.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      Conserved Domains (1) summary
      PRK08912
      Location:218569
      PRK08912; aminotransferase
    2. XM_030252061.2XP_030107921.1  kynurenine--oxoglutarate transaminase 1 isoform X4

      Conserved Domains (1) summary
      PRK08912
      Location:2333
      PRK08912; aminotransferase
    3. XM_036162561.1XP_036018454.1  kynurenine--oxoglutarate transaminase 1 isoform X3

      Conserved Domains (1) summary
      PRK08912
      Location:3362
      PRK08912; aminotransferase
    4. XM_036162562.1XP_036018455.1  kynurenine--oxoglutarate transaminase 1 isoform X4

      UniProtKB/TrEMBL
      A2AQY8
      Conserved Domains (1) summary
      PRK08912
      Location:2333
      PRK08912; aminotransferase
    5. XM_006498317.4XP_006498380.1  kynurenine--oxoglutarate transaminase 1 isoform X2

      Conserved Domains (1) summary
      PRK08912
      Location:25391
      PRK08912; aminotransferase

    RNA

    1. XR_003953717.1 RNA Sequence

    2. XR_001783175.2 RNA Sequence