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    Fezf2 Fez family zinc finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 54713, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fezf2provided by MGI
    Official Full Name
    Fez family zinc finger 2provided by MGI
    Primary source
    MGI:MGI:1859823
    See related
    Ensembl:ENSMUSG00000021743 AllianceGenome:MGI:1859823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fez; Fezl; Zfp312
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell dedifferentiation; positive regulation of DNA-templated transcription; and regulation of neurogenesis. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future prosencephalon; retina; thymus; and vomeronasal organ. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 17.8), whole brain E14.5 (RPKM 14.5) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fezf2 in Genome Data Viewer
    Location:
    14 A1; 14 6.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (10121561..10130771)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (12338992..12346803, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Ca2+-dependent secretion activator Neighboring gene STARR-seq mESC enhancer starr_35957 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35956 Neighboring gene STARR-seq mESC enhancer starr_35954 Neighboring gene predicted gene, 24578 Neighboring gene centrosomal protein 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of GABAergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell dedifferentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fez family zinc finger protein 2
    Names
    forebrain embryonic zinc finger
    forebrain embryonic zinc finger-like protein 2
    zinc finger protein 312

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080433.3NP_536681.2  fez family zinc finger protein 2

      See identical proteins and their annotated locations for NP_536681.2

      Status: VALIDATED

      Source sequence(s)
      AI325906, AK019996, BM963196, BU703203
      Consensus CDS
      CCDS26818.1
      UniProtKB/Swiss-Prot
      Q9D298, Q9ESP5
      Related
      ENSMUSP00000022262.5, ENSMUST00000022262.6
      Conserved Domains (4) summary
      COG5048
      Location:284390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317339
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      10121561..10130771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247890.2XP_030103750.1  fez family zinc finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9D298, Q9ESP5
      Conserved Domains (4) summary
      COG5048
      Location:284390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317339
      zf-H2C2_2; Zinc-finger double domain
    2. XM_036158763.1XP_036014656.1  fez family zinc finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9D298, Q9ESP5
      Related
      ENSMUSP00000153090.2, ENSMUST00000224714.2
      Conserved Domains (4) summary
      COG5048
      Location:284390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317339
      zf-H2C2_2; Zinc-finger double domain