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    Ap5m1 adaptor related protein complex 5 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap5m1provided by RGD
    Official Full Name
    adaptor related protein complex 5 subunit mu 1provided by RGD
    Primary source
    RGD:1308087
    See related
    EnsemblRapid:ENSRNOG00000014148 AllianceGenome:RGD:1308087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mu5; Mudeng; RGD1308087
    Summary
    Predicted to be involved in endosomal transport. Predicted to be located in membrane. Predicted to be part of AP-type membrane coat adaptor complex. Predicted to be active in cytosol; late endosome; and lysosome. Orthologous to human AP5M1 (adaptor related protein complex 5 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 137.4), Thymus (RPKM 128.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap5m1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (24835122..24864854)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (22355478..22385222)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (25933483..25955745)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene biogenesis of ribosomes BRX1, pseudogene 2 Neighboring gene exocyst complex component 5 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit Neighboring gene coiled-coil domain containing 198

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The fifth adaptor protein complex. Hirst J, et al. PLoS Biol, 2011 Oct. PMID 22022230, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC124703

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-type membrane coat adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-type membrane coat adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AP-type membrane coat adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AP-5 complex subunit mu-1
    Names
    MHD domain-containing death-inducing protein
    MU-2/AP1M2 domain containing, death-inducing
    adapter-related protein complex 5 mu subunit
    adapter-related protein complex 5 subunit mu-1
    adaptor-related protein complex 5, mu 1 subunit
    mu-2-related death-inducing protein
    muD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030036.1 → NP_001025207.1  AP-5 complex subunit mu-1

      See identical proteins and their annotated locations for NP_001025207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099829
      UniProtKB/Swiss-Prot
      Q499N2
      UniProtKB/TrEMBL
      A0A8L2Q9R9, A6KE84
      Related
      ENSRNOP00000106654.1, ENSRNOT00000126250.1
      Conserved Domains (1) summary
      cd09256
      Location:196 → 482
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      24835122..24864854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093286.2 → XP_038949214.1  AP-5 complex subunit mu-1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q9R9
      Related
      ENSRNOP00000090061.2, ENSRNOT00000096073.2
      Conserved Domains (1) summary
      cd09256
      Location:196 → 470
      AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

    2. XM_039093287.2 → XP_038949215.1  AP-5 complex subunit mu-1 isoform X2

      Conserved Domains (1) summary
      cl10970
      Location:196 → 316
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RNA

    1. XR_005493717.2 RNA Sequence

    2. XR_010057813.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499N2.1 GenPept UniProtKB/Swiss-Prot:Q499N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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