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    ZDS1 Zds1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZDS1
    Official Full Name
    Zds1p
    Primary source
    SGD:S000004886
    Locus tag
    YMR273C
    See related
    AllianceGenome:SGD:S000004886; FungiDB:YMR273C; VEuPathDB:YMR273C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CES1; CKM1; NRC1; OSS1
    Summary
    Enables protein phosphatase inhibitor activity. Involved in several processes, including heterochromatin formation; mRNA export from nucleus; and positive regulation of G2/M transition of mitotic cell cycle. Located in several cellular components, including cellular bud neck; cellular bud tip; and incipient cellular bud site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZDS1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (811233..813980, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene fatty acid alpha-hydroxylase Neighboring gene uncharacterized protein Neighboring gene CAAX prenyl protease Neighboring gene ubiquitin-ubiquitin ligase BUL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A positive screening for drugs that specifically inhibit the Ca2+-signaling activity on the basis of the growth promoting effect on a yeast mutant with a peculiar phenotype. Shitamukai A, et al. Biosci Biotechnol Biochem, 2000 Sep. PMID 11055400
    2. Pinostrobin from Boesenbergia pandurata is an inhibitor of Ca2+-signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae. Wangkangwan W, et al. Biosci Biotechnol Biochem, 2009 Jul. PMID 19584530
    3. Identification of Saccharomyces cerevisiae Tub1 alpha-tubulin as a potential target for NKH-7, a cytotoxic 1-naphthol derivative compound. Chanklan R, et al. Biosci Biotechnol Biochem, 2008 Apr. PMID 18391444
    4. Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae. Zhang A, et al. FEMS Microbiol Lett, 2012 Jun. PMID 22428880
    5. Stabilization of mini-chromosome segregation during mitotic growth by overexpression of YCR041W and its application to chromosome engineering in Saccharomyces cerevisiae. Sasano Y, et al. J Biosci Bioeng, 2015 May. PMID 25454064

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Igo1/Igo2 can inhibit Cdc55 in early mitosis, but their contribution to Cdc55 regulation is relatively minor compared with the role of Zds1/Zds2.
      Title: Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
    2. Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif.
      Title: Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif.
    3. These data indicated that Sch9 regulated localization of Bcy1 via Zds1.
      Title: Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae.
    4. regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast
      Title: Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.
    5. Zds1 and Zds2 are components of the mitotic exit machinery, involved in activation of the Cdc14 phosphatase at anaphase onset.
      Title: Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase.
    6. Zds1p associates with the complex formed by fungal proteins and nucleoporins at the cytosolic fibrils of the nuclear pore complex and is required for optimal mRNA export.
      Title: Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zds1p
    NP_014000.1
    • Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      811233..813980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182780.1 → NP_014000.1  TPA: Zds1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0A0, P41373, P50111
      UniProtKB/TrEMBL
      B3LMG1, C8ZFE0
      Conserved Domains (2) summary
      PRK00404
      Location:732 → 809
      tatB; Sec-independent protein translocase subunit TatB
      pfam08632
      Location:845 → 893
      Zds_C; Activator of mitotic machinery Cdc14 phosphatase activation C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50111.1

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