Ric8a RIC8 guanine nucleotide exchange factor A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ric8aprovided by RGD
Official Full Name: RIC8 guanine nucleotide exchange factor Aprovided by RGD
Primary source: RGD:727957
See related: EnsemblRapid:ENSRNOG00000013256 AllianceGenome:RGD:727957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ric8; Ric-8A
Summary: Enables G-protein alpha-subunit binding activity; GTPase regulator activity; and protein folding chaperone. Involved in G protein-coupled receptor signaling pathway. Located in cytoplasm and plasma membrane. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 187.0), Adrenal (RPKM 176.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205364796..205371102)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (195935162..195941469)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213606599..213612905)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure, function, and dynamics of the Galpha binding domain of Ric-8A have been reported.
Title: Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.
In contrast to G protein-coupled receptors, Ric-8A interacts with Switches I and II of Galpha and possibly at the Galpha domain interface.
Title: Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.
Induction of Galphai1 structural heterogeneity by Ric-8A provides a mechanism for nucleotide release
Title: Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.
RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A
Title: G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.
The C-terminus of Galphai1 is shown to be a critical binding element for Ric-8A.
Title: The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.
Ric-8A has a role in catalyzing guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3
Title: Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration involved in gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion involved in gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synembryn-A

Names: heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8A; resistance to inhibitors of cholinesterase 8A-like protein; synembryn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100520.1 → NP_001093990.1 synembryn-A

See identical proteins and their annotated locations for NP_001093990.1

Status: PROVISIONAL

Source sequence(s)

BC160852

UniProtKB/Swiss-Prot

Q80ZG1

UniProtKB/TrEMBL

B1H241, F7F506

Related

ENSRNOP00000018470.4, ENSRNOT00000018470.7

Conserved Domains (1) summary

pfam10165
Location:67 → 497

Ric8; Guanine nucleotide exchange factor synembryn

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205364796..205371102

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107824.2 → XP_038963752.1 synembryn-A isoform X1

Conserved Domains (1) summary

pfam10165
Location:2 → 381

Ric8; Guanine nucleotide exchange factor synembryn