U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pecr peroxisomal trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

    Gene ID: 111175, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pecrprovided by MGI
    Official Full Name
    peroxisomal trans-2-enoyl-CoA reductaseprovided by MGI
    Primary source
    MGI:MGI:2148199
    See related
    Ensembl:ENSMUSG00000026189 AllianceGenome:MGI:2148199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TERP; 2400003B18Rik
    Summary
    Predicted to enable signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in phytol metabolic process. Predicted to act upstream of or within fatty acid elongation. Located in mitochondrion. Is expressed in alimentary system; gland; heart; liver; and pancreas. Orthologous to human PECR (peroxisomal trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 84.9), kidney adult (RPKM 79.9) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pecr in Genome Data Viewer
    Location:
    1 C3; 1 36.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72298331..72323480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72259172..72284321, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D230017M19 gene Neighboring gene STARR-seq mESC enhancer starr_01271 Neighboring gene STARR-positive B cell enhancer ABC_E5771 Neighboring gene predicted gene, 24497 Neighboring gene predicted gene, 25939 Neighboring gene transmembrane protein 169 Neighboring gene predicted gene, 51631 Neighboring gene STARR-positive B cell enhancer ABC_E4322 Neighboring gene STARR-seq mESC enhancer starr_01273 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 Neighboring gene STARR-seq mESC enhancer starr_01274

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid elongation ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in phytol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phytol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phytol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal trans-2-enoyl-CoA reductase
    Names
    perosisomal 2-enoyl-CoA reductase
    NP_001343445.1
    NP_076012.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356516.1NP_001343445.1  peroxisomal trans-2-enoyl-CoA reductase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its' 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC114905, AC120136
      Conserved Domains (1) summary
      cl25409
      Location:2121
      SDR; Short-chain dehydrogenases/reductases (SDR)
    2. NM_023523.6NP_076012.3  peroxisomal trans-2-enoyl-CoA reductase isoform 1

      See identical proteins and their annotated locations for NP_076012.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK010260, AK162100, BY286611, CB723327
      Consensus CDS
      CCDS35607.1
      UniProtKB/Swiss-Prot
      Q99MZ7, Q9CX01, Q9JIF4
      UniProtKB/TrEMBL
      Q3UXD9
      Related
      ENSMUSP00000027381.7, ENSMUST00000027381.13
      Conserved Domains (2) summary
      cd05369
      Location:32267
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK05653
      Location:32267
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72298331..72323480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)