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    Pierce1 piercer of microtubule wall 1 [ Mus musculus (house mouse) ]

    Gene ID: 69327, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pierce1provided by MGI
    Official Full Name
    piercer of microtubule wall 1provided by MGI
    Primary source
    MGI:MGI:1916577
    See related
    Ensembl:ENSMUSG00000026831 AllianceGenome:MGI:1916577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbest47; 1700007K13Rik
    Summary
    Involved in axoneme assembly; establishment of left/right asymmetry; and flagellated sperm motility. Acts upstream of or within DNA damage response; cellular response to UV-C; and regulation of gene expression. Located in cytoplasm and nucleus. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in brain; genitourinary system; lung; node; and retina. Orthologous to human PIERCE1 (piercer of microtubule wall 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 17.2), lung adult (RPKM 3.3) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pierce1 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28352013..28356336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28462001..28466324, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13373 Neighboring gene STARR-seq mESC enhancer starr_04019 Neighboring gene protein phosphatase 1, regulatory subunit 26 Neighboring gene STARR-seq mESC enhancer starr_04020 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_04022

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Clone Names

    • MGC118342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    piercer of microtubule wall 1 protein
    Names
    UPF0691 protein C9orf116 homolog
    p53-induced expression in RB-null cells protein 1
    pierce 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027040.1NP_081316.1  piercer of microtubule wall 1 protein

      See identical proteins and their annotated locations for NP_081316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099566
      Consensus CDS
      CCDS15837.1
      UniProtKB/Swiss-Prot
      Q5BN45
      Related
      ENSMUSP00000083557.5, ENSMUST00000086370.11
      Conserved Domains (1) summary
      pfam14892
      Location:49137
      DUF4490; Domain of unknown function (DUF4490)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28352013..28356336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)